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3kvd

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[[Image:3kvd.jpg|left|200px]]
 
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==Crystal structure of the Neisseria meningitidis Factor H binding protein, fHbp (GNA1870) at 2.0 A resolution==
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The line below this paragraph, containing "STRUCTURE_3kvd", creates the "Structure Box" on the page.
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<StructureSection load='3kvd' size='340' side='right'caption='[[3kvd]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KVD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvd OCA], [https://pdbe.org/3kvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kvd RCSB], [https://www.ebi.ac.uk/pdbsum/3kvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kvd ProSAT]</span></td></tr>
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{{STRUCTURE_3kvd| PDB=3kvd | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q6QCC2_NEIME Q6QCC2_NEIME]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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fHbp, a highly immunogenic outer membrane protein of Neisseria meningitidis, is responsible for binding to human factor H, a multi-domain protein which is the central regulator of the alternative complement pathway. Here, the crystal structure of mature fHbp determined at 2 A resolution is presented and is compared with the structure of the same protein in complex with factor H domains 6 and 7 recently solved using X-ray techniques. While the overall protein fold is well conserved, modifications are observed mainly in the loop regions involved in the interaction, reflecting a specific adaptation of fHbp in complexing factor H with high affinity. Such a comparison has to date been impaired by the fact that fHbp models determined by NMR show remarkable differences over the entire structure.
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===Crystal structure of the Neisseria meningitidis Factor H binding protein, fHbp (GNA1870) at 2.0 A resolution===
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Structure of the uncomplexed Neisseria meningitidis factor H-binding protein fHbp (rLP2086).,Cendron L, Veggi D, Girardi E, Zanotti G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt, 5):531-5. Epub 2011 Apr 20. PMID:21543855<ref>PMID:21543855</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3kvd]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Neisseria_meningitidis Neisseria meningitidis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVD OCA].
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<div class="pdbe-citations 3kvd" style="background-color:#fffaf0;"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:19225461</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Neisseria meningitidis]]
[[Category: Neisseria meningitidis]]
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[[Category: Cendron, L.]]
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[[Category: Cendron L]]
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[[Category: Girardi, E.]]
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[[Category: Girardi E]]
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[[Category: Veggi, D.]]
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[[Category: Veggi D]]
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[[Category: Zanotti, G.]]
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[[Category: Zanotti G]]
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[[Category: Alternative complement pathway]]
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[[Category: Antigen]]
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[[Category: Lipoprotein]]
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[[Category: Meningococcal vaccine]]
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[[Category: Protein binding]]
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Current revision

Crystal structure of the Neisseria meningitidis Factor H binding protein, fHbp (GNA1870) at 2.0 A resolution

PDB ID 3kvd

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