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3kvz

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Current revision (08:25, 6 September 2023) (edit) (undo)
 
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==Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thiesterase FlK - wild type FlK in complex with FAcCPan==
==Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thiesterase FlK - wild type FlK in complex with FAcCPan==
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<StructureSection load='3kvz' size='340' side='right' caption='[[3kvz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3kvz' size='340' side='right'caption='[[3kvz]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3kvz]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/"streptomyces_cattleya"_kahan_et_al._1979 "streptomyces cattleya" kahan et al. 1979]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KVZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3kvz]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KVZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ENV:(2R)-N-{3-[(5-FLUORO-4-OXOPENTYL)AMINO]-3-OXOPROPYL}-2,4-DIHYDROXY-3,3-DIMETHYLBUTANAMIDE'>ENV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3kuv|3kuv]], [[3kuw|3kuw]], [[3kv7|3kv7]], [[3kv8|3kv8]], [[3kvi|3kvi]], [[3kvu|3kvu]], [[3kw1|3kw1]], [[3kx7|3kx7]], [[3kx8|3kx8]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ENV:(2R)-N-{3-[(5-FLUORO-4-OXOPENTYL)AMINO]-3-OXOPROPYL}-2,4-DIHYDROXY-3,3-DIMETHYLBUTANAMIDE'>ENV</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">flK, fluoroacetyl-CoA thioesterase FlK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=29303 "Streptomyces cattleya" Kahan et al. 1979])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvz OCA], [https://pdbe.org/3kvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kvz RCSB], [https://www.ebi.ac.uk/pdbsum/3kvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kvz ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kvz OCA], [http://pdbe.org/3kvz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kvz RCSB], [http://www.ebi.ac.uk/pdbsum/3kvz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kvz ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT]] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref>
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[https://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</div>
</div>
<div class="pdbe-citations 3kvz" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3kvz" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Streptomyces cattleya kahan et al. 1979]]
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[[Category: Large Structures]]
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[[Category: Blundell, T L]]
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[[Category: Streptomyces cattleya]]
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[[Category: Chirgadze, D Y]]
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[[Category: Blundell TL]]
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[[Category: Dias, M V.B]]
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[[Category: Chirgadze DY]]
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[[Category: Huang, F]]
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[[Category: Dias MVB]]
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[[Category: Leadlay, P F]]
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[[Category: Huang F]]
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[[Category: Spencer, J B]]
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[[Category: Leadlay PF]]
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[[Category: Spiteller, D]]
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[[Category: Spencer JB]]
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[[Category: Tosin, M]]
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[[Category: Spiteller D]]
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[[Category: Valentine, E F]]
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[[Category: Tosin M]]
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[[Category: Fluoroacetyl-coa thioesterase flk]]
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[[Category: Valentine EF]]
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[[Category: Hot-dog folding]]
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[[Category: Hydrolase]]
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[[Category: Thioesterase]]
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Current revision

Structural basis of the activity and substrate specificity of the fluoroacetyl-CoA thiesterase FlK - wild type FlK in complex with FAcCPan

PDB ID 3kvz

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