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3l9n

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==crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27==
==crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27==
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<StructureSection load='3l9n' size='340' side='right' caption='[[3l9n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3l9n' size='340' side='right'caption='[[3l9n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3l9n]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3L9N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3l9n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L9N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L9N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=L9N:(2S)-N~1~-[5-(1H-INDAZOL-5-YL)-1,3,4-THIADIAZOL-2-YL]-3-(4-METHYLPHENYL)PROPANE-1,2-DIAMINE'>L9N</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=L9N:(2S)-N~1~-[5-(1H-INDAZOL-5-YL)-1,3,4-THIADIAZOL-2-YL]-3-(4-METHYLPHENYL)PROPANE-1,2-DIAMINE'>L9N</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3l9l|3l9l]], [[3l9m|3l9m]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9n OCA], [https://pdbe.org/3l9n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l9n RCSB], [https://www.ebi.ac.uk/pdbsum/3l9n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l9n ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PRKACA, PKACA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), PKIA, PRKACN1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/cAMP-dependent_protein_kinase cAMP-dependent protein kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.11 2.7.11.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3l9n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l9n OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3l9n RCSB], [http://www.ebi.ac.uk/pdbsum/3l9n PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/IPKA_HUMAN IPKA_HUMAN] Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3l9n" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[CAMP-dependent protein kinase 3D structures|CAMP-dependent protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: CAMP-dependent protein kinase]]
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[[Category: Large Structures]]
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[[Category: Huang, X]]
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[[Category: Huang X]]
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[[Category: Inhibitor]]
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[[Category: Pkb]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

crystal structure of PKAB3 (pka triple mutant V123A, L173M, Q181K) with compound 27

PDB ID 3l9n

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