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3lfp

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[[Image:3lfp.jpg|left|200px]]
 
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==Crystal Structure of the Restriction-Modification Controller Protein C.Csp231I==
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The line below this paragraph, containing "STRUCTURE_3lfp", creates the "Structure Box" on the page.
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<StructureSection load='3lfp' size='340' side='right'caption='[[3lfp]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3lfp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Citrobacter_sp._RFL231 Citrobacter sp. RFL231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LFP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LFP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lfp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lfp OCA], [https://pdbe.org/3lfp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lfp RCSB], [https://www.ebi.ac.uk/pdbsum/3lfp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lfp ProSAT]</span></td></tr>
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{{STRUCTURE_3lfp| PDB=3lfp | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q32WH4_9ENTR Q32WH4_9ENTR]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Controller proteins play a key role in the temporal regulation of gene expression in bacterial restriction-modification (R-M) systems and are important mediators of horizontal gene transfer. They form the basis of a highly cooperative, concentration-dependent genetic switch involved in both activation and repression of R-M genes. Here we present biophysical, biochemical, and high-resolution structural analyses of a novel class of controller proteins, exemplified by C.Csp231I. In contrast to all previously solved C-protein structures, each protein subunit has two extra helices at the C-terminus, which play a large part in maintaining the dimer interface. The DNA binding site of the protein is also novel, having largely AAAA tracts between the palindromic recognition half-sites, suggesting tight bending of the DNA. The protein structure shows an unusual positively charged surface that could form the basis for wrapping the DNA completely around the C-protein dimer.
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===Crystal Structure of the Restriction-Modification Controller Protein C.Csp231I===
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Structural Analysis of a Novel Class of R-M Controller Proteins: C.Csp231I from Citrobacter sp. RFL231.,McGeehan JE, Streeter SD, Thresh SJ, Taylor JE, Shevtsov MB, Kneale GG J Mol Biol. 2011 Mar 31. PMID:21440553<ref>PMID:21440553</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3lfp]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Citrobacter_sp._rfl231 Citrobacter sp. rfl231]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LFP OCA].
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<div class="pdbe-citations 3lfp" style="background-color:#fffaf0;"></div>
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[[Category: Citrobacter sp. rfl231]]
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== References ==
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[[Category: Kneale, G G.]]
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<references/>
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[[Category: McGeehan, J E.]]
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__TOC__
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[[Category: Streeter, S D.]]
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</StructureSection>
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[[Category: Thresh, S J.]]
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[[Category: Citrobacter sp. RFL231]]
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[[Category: Large Structures]]
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[[Category: Kneale GG]]
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[[Category: McGeehan JE]]
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[[Category: Streeter SD]]
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[[Category: Thresh SJ]]

Current revision

Crystal Structure of the Restriction-Modification Controller Protein C.Csp231I

PDB ID 3lfp

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