This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3llk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (08:39, 6 September 2023) (edit) (undo)
 
(8 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3llk.jpg|left|200px]]
 
-
<!--
+
==Sulfhydryl Oxidase Fragment of Human QSOX1==
-
The line below this paragraph, containing "STRUCTURE_3llk", creates the "Structure Box" on the page.
+
<StructureSection load='3llk' size='340' side='right'caption='[[3llk]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3llk]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LLK FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene></td></tr>
-
{{STRUCTURE_3llk| PDB=3llk | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3llk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3llk OCA], [https://pdbe.org/3llk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3llk RCSB], [https://www.ebi.ac.uk/pdbsum/3llk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3llk ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/QSOX1_HUMAN QSOX1_HUMAN] Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation.<ref>PMID:16806532</ref> <ref>PMID:10542195</ref> <ref>PMID:10708601</ref> <ref>PMID:12176051</ref> <ref>PMID:17331072</ref> <ref>PMID:18393449</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ll/3llk_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3llk ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Quiescin sulfhydryl oxidase (QSOX) catalyzes formation of disulfide bonds between cysteine residues in substrate proteins. Human QSOX1 is a multi-domain, monomeric enzyme containing a module related to the single-domain sulfhydryl oxidases of the Erv family. A partial QSOX1 crystal structure reveals a single-chain pseudo-dimer mimicking the quaternary structure of Erv enzymes. However, one pseudo-dimer "subunit" has lost its cofactor and catalytic activity. In QSOX evolution, a further concatenation to a member of the protein disulfide isomerase family resulted in an enzyme capable of both disulfide formation and efficient transfer to substrate proteins.
-
===Sulfhydryl Oxidase Fragment of Human QSOX1===
+
QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains.,Alon A, Heckler EJ, Thorpe C, Fass D FEBS Lett. 2010 Apr 16;584(8):1521-5. Epub 2010 Mar 6. PMID:20211621<ref>PMID:20211621</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3llk" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20211621}}, adds the Publication Abstract to the page
+
*[[Sulfhydryl oxidase 3D structures|Sulfhydryl oxidase 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 20211621 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_20211621}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
3LLK is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LLK OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:20211621</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Thiol oxidase]]
+
[[Category: Large Structures]]
-
[[Category: Alon, A.]]
+
[[Category: Alon A]]
-
[[Category: Fass, D.]]
+
[[Category: Fass D]]
-
[[Category: Alternative splicing]]
+
-
[[Category: Disulfide]]
+
-
[[Category: Fad]]
+
-
[[Category: Flavin adenine dinucleotide]]
+
-
[[Category: Flavoprotein]]
+
-
[[Category: Glycoprotein]]
+
-
[[Category: Golgi apparatus]]
+
-
[[Category: Membrane]]
+
-
[[Category: Oxidoreductase]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Secreted]]
+
-
[[Category: Sulfhydryl oxidase]]
+
-
[[Category: Transmembrane]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 31 13:43:52 2010''
+

Current revision

Sulfhydryl Oxidase Fragment of Human QSOX1

PDB ID 3llk

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3llk"
Personal tools