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3lpf

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==Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea==
==Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea==
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<StructureSection load='3lpf' size='340' side='right' caption='[[3lpf]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
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<StructureSection load='3lpf' size='340' side='right'caption='[[3lpf]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lpf]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LPF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lpf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LPF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LPF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=Z77:1-[(6,7-DIMETHYL-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)METHYL]-1-(2-HYDROXYETHYL)-3-(3-METHOXYPHENYL)THIOUREA'>Z77</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=Z77:1-[(6,7-DIMETHYL-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)METHYL]-1-(2-HYDROXYETHYL)-3-(3-METHOXYPHENYL)THIOUREA'>Z77</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3k4a|3k4a]], [[3k46|3k46]], [[3k4d|3k4d]], [[3lpg|3lpg]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpf OCA], [https://pdbe.org/3lpf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lpf RCSB], [https://www.ebi.ac.uk/pdbsum/3lpf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lpf ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">b1617, gurA, gusA, JW1609, uidA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Beta-glucuronidase Beta-glucuronidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.31 3.2.1.31] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lpf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lpf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lpf RCSB], [http://www.ebi.ac.uk/pdbsum/3lpf PDBsum]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BGLR_ECOLI BGLR_ECOLI]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3lpf" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glucuronidase|Glucuronidase]]
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*[[Glucuronisidase 3D structures|Glucuronisidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Beta-glucuronidase]]
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[[Category: Escherichia coli K-12]]
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[[Category: Escherichia coli]]
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[[Category: Large Structures]]
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[[Category: Redinbo, M R]]
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[[Category: Redinbo MR]]
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[[Category: Wallace, B D]]
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[[Category: Wallace BD]]
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[[Category: Alpha/beta barrel]]
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[[Category: Beta-glucuronidase inhibitor]]
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[[Category: Beta-sandwich domain]]
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[[Category: Glycosidase]]
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[[Category: Glycosyl hydrolase]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Sugar-binding domain]]
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Current revision

Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea

PDB ID 3lpf

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