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3lw2

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Current revision (08:44, 6 September 2023) (edit) (undo)
 
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==Mouse Plasminogen Activator Inhibitor-1 (PAI-1)==
==Mouse Plasminogen Activator Inhibitor-1 (PAI-1)==
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<StructureSection load='3lw2' size='340' side='right' caption='[[3lw2]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
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<StructureSection load='3lw2' size='340' side='right'caption='[[3lw2]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lw2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LW2 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lw2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LW2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LW2 FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1c5g|1c5g]], [[1dvn|1dvn]], [[1lj5|1lj5]], [[1db2|1db2]], [[3eox|3eox]], [[9pai|9pai]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Serpine1, Mr1, Pai1, Planh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lw2 OCA], [https://pdbe.org/3lw2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lw2 RCSB], [https://www.ebi.ac.uk/pdbsum/3lw2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lw2 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lw2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lw2 OCA], [http://pdbe.org/3lw2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lw2 RCSB], [http://www.ebi.ac.uk/pdbsum/3lw2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lw2 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PAI1_MOUSE PAI1_MOUSE]] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity).
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[https://www.uniprot.org/uniprot/PAI1_MOUSE PAI1_MOUSE] Serine protease inhibitor. This inhibitor acts as 'bait' for tissue plasminogen activator, urokinase, protein C and matriptase-3/TMPRSS7. Its rapid interaction with PLAT may function as a major control point in the regulation of fibrinolysis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw2_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lw2_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 3lw2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3lw2" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Plasminogen activator inhibitor|Plasminogen activator inhibitor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lk3 transgenic mice]]
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[[Category: Large Structures]]
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[[Category: Compernolle, G]]
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[[Category: Mus musculus]]
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[[Category: Craen, B Van De]]
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[[Category: Compernolle G]]
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[[Category: Declerck, P J]]
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[[Category: Declerck PJ]]
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[[Category: Dewilde, M]]
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[[Category: Dewilde M]]
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[[Category: Gils, A]]
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[[Category: Gils A]]
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[[Category: Madsen, J B]]
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[[Category: Madsen JB]]
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[[Category: Strelkov, S V]]
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[[Category: Strelkov SV]]
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[[Category: Glycoprotein]]
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[[Category: Van De Craen B]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Plasminogen activation]]
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Current revision

Mouse Plasminogen Activator Inhibitor-1 (PAI-1)

PDB ID 3lw2

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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