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3lwe

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==The crystal structure of MPP8==
==The crystal structure of MPP8==
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<StructureSection load='3lwe' size='340' side='right' caption='[[3lwe]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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<StructureSection load='3lwe' size='340' side='right'caption='[[3lwe]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lwe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LWE FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LWE FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3r93|3r93]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPHOSPH8, MPP8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwe OCA], [https://pdbe.org/3lwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lwe RCSB], [https://www.ebi.ac.uk/pdbsum/3lwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwe ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lwe OCA], [http://pdbe.org/3lwe PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lwe RCSB], [http://www.ebi.ac.uk/pdbsum/3lwe PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lwe ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN]] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref>
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[https://www.uniprot.org/uniprot/MPP8_HUMAN MPP8_HUMAN] Involved in transcriptional regulation. Specifically recognizes and binds methylated 'Lys-9' of histone H3 (H3K9me) and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation of CDH1 expression.<ref>PMID:20871592</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwe_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lw/3lwe_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Crombet, L]]
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[[Category: Large Structures]]
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[[Category: Li, Z]]
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[[Category: Crombet L]]
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[[Category: Min, J]]
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[[Category: Li Z]]
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[[Category: Pan, P W]]
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[[Category: Min J]]
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[[Category: Ruan, J]]
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[[Category: Pan PW]]
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[[Category: Tempel, W]]
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[[Category: Ruan J]]
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[[Category: Tong, Y]]
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[[Category: Tempel W]]
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[[Category: Xu, C]]
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[[Category: Tong Y]]
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[[Category: Zang, J]]
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[[Category: Xu C]]
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[[Category: Ank repeat]]
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[[Category: Zang J]]
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[[Category: Cell cycle]]
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[[Category: Mpp8]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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Current revision

The crystal structure of MPP8

PDB ID 3lwe

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OCA

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