1mqw

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[[Image:1mqw.jpg|left|200px]]
[[Image:1mqw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1mqw |SIZE=350|CAPTION= <scene name='initialview01'>1mqw</scene>, resolution 2.3&Aring;
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The line below this paragraph, containing "STRUCTURE_1mqw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ADV:ALPHA-BETA+METHYLENE+ADP-RIBOSE'>ADV</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/ADP-ribose_diphosphatase ADP-ribose diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.13 3.6.1.13] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= Rv1700 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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-->
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|DOMAIN=
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{{STRUCTURE_1mqw| PDB=1mqw | SCENE= }}
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|RELATEDENTRY=[[1mk1|1mk1]], [[1mp2|1mp2]], [[1mqw|1MQW]], [[1mr2|1MR2]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1mqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1mqw OCA], [http://www.ebi.ac.uk/pdbsum/1mqw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1mqw RCSB]</span>
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}}
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'''Structure of the MT-ADPRase in complex with three Mn2+ ions and AMPCPR, a Nudix enzyme'''
'''Structure of the MT-ADPRase in complex with three Mn2+ ions and AMPCPR, a Nudix enzyme'''
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[[Category: Handley, S F.O.]]
[[Category: Handley, S F.O.]]
[[Category: Kang, L W.]]
[[Category: Kang, L W.]]
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[[Category: adpr]]
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[[Category: Adpr]]
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[[Category: mycobacterium tuberculosis]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: nudix hydrolase]]
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[[Category: Nudix hydrolase]]
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[[Category: rv1700]]
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[[Category: Rv1700]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 01:36:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:19:56 2008''
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Revision as of 22:36, 2 May 2008

Image:1mqw.jpg

Template:STRUCTURE 1mqw

Structure of the MT-ADPRase in complex with three Mn2+ ions and AMPCPR, a Nudix enzyme


Overview

Nudix hydrolases are a family of proteins that contain the characteristic sequence GX(5)EX(7)REUXEEXG(I/L/V), the Nudix box. They catalyze the hydrolysis of a variety of nucleoside diphosphate derivatives such as ADP-ribose, Ap(n)A (3 </= n </= 6), NADH, and dATP. A number of Nudix hydrolases from several species, ranging from bacteria to humans, have been characterized, including, in some cases, the determination of their three-dimensional structures. The product of the Rv1700 gene of M. tuberculosis is a Nudix hydrolase specific for ADP-ribose (ADPR). We have determined the crystal structures of MT-ADPRase alone, and in complex with substrate, with substrate and the nonactivating metal ion Gd(3+), and in complex with a nonhydrolyzable ADPR analog and the activating metal ion Mn(2+). These structures, refined with data extending to resolutions between 2.0 and 2.3 A, showed that there are sequence differences in binding site residues between MT-ADPRase and a human homolog that may be exploited for antituberculosis drug development.

About this Structure

1MQW is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure and mechanism of MT-ADPRase, a nudix hydrolase from Mycobacterium tuberculosis., Kang LW, Gabelli SB, Cunningham JE, O'Handley SF, Amzel LM, Structure. 2003 Aug;11(8):1015-23. PMID:12906832 Page seeded by OCA on Sat May 3 01:36:45 2008

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