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3mng

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Current revision (08:56, 6 September 2023) (edit) (undo)
 
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==wild type human PrxV with DTT bound as a competitive inhibitor==
==wild type human PrxV with DTT bound as a competitive inhibitor==
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<StructureSection load='3mng' size='340' side='right' caption='[[3mng]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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<StructureSection load='3mng' size='340' side='right'caption='[[3mng]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mng]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MNG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mng]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MNG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MNG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hd2|1hd2]], [[1h4o|1h4o]], [[1oc3|1oc3]], [[1urm|1urm]], [[2vl2|2vl2]], [[2vl3|2vl3]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene>, <scene name='pdbligand=D1D:(4S,5S)-1,2-DITHIANE-4,5-DIOL'>D1D</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ACR1, aoeb166, arc1, pmp20, PRDX5, SBBI10 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mng OCA], [https://pdbe.org/3mng PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mng RCSB], [https://www.ebi.ac.uk/pdbsum/3mng PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mng ProSAT]</span></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peroxiredoxin Peroxiredoxin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.15 1.11.1.15] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mng OCA], [http://pdbe.org/3mng PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mng RCSB], [http://www.ebi.ac.uk/pdbsum/3mng PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mng ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/PRDX5_HUMAN PRDX5_HUMAN]] Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
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[https://www.uniprot.org/uniprot/PRDX5_HUMAN PRDX5_HUMAN] Reduces hydrogen peroxide and alkyl hydroperoxides with reducing equivalents provided through the thioredoxin system. Involved in intracellular redox signaling.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Peroxiredoxin|Peroxiredoxin]]
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*[[Peroxiredoxin 3D structures|Peroxiredoxin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Peroxiredoxin]]
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[[Category: Large Structures]]
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[[Category: Hall, A]]
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[[Category: Hall A]]
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[[Category: Karplus, P A]]
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[[Category: Karplus PA]]
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[[Category: Dtt]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxidase]]
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[[Category: Prxv]]
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[[Category: Substrate analog]]
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Current revision

wild type human PrxV with DTT bound as a competitive inhibitor

PDB ID 3mng

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