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3mtt

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Current revision (09:01, 6 September 2023) (edit) (undo)
 
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==Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target HR5531C==
==Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target HR5531C==
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<StructureSection load='3mtt' size='340' side='right' caption='[[3mtt]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
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<StructureSection load='3mtt' size='340' side='right'caption='[[3mtt]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3mtt]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTT OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MTT FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3mtt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MTT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MTT FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIK3R2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3mtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtt OCA], [http://pdbe.org/3mtt PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3mtt RCSB], [http://www.ebi.ac.uk/pdbsum/3mtt PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtt ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mtt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mtt OCA], [https://pdbe.org/3mtt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mtt RCSB], [https://www.ebi.ac.uk/pdbsum/3mtt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mtt ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN]] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
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[https://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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==See Also==
==See Also==
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*[[Phosphoinositide 3-Kinases|Phosphoinositide 3-Kinases]]
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Guan, R]]
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[[Category: Large Structures]]
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[[Category: Krug, R M]]
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[[Category: Guan R]]
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[[Category: Ma, L C]]
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[[Category: Krug RM]]
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[[Category: Montelione, G T]]
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[[Category: Ma LC]]
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[[Category: Structural genomic]]
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[[Category: Montelione GT]]
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[[Category: Schauder, C]]
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[[Category: Schauder C]]
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[[Category: Inter-sh2 domain]]
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[[Category: Nesg]]
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[[Category: Pi3-kinase subunit p85-beta]]
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[[Category: Protein binding]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Signaling protein]]
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Current revision

Crystal structure of iSH2 domain of human p85beta, Northeast Structural Genomics Consortium Target HR5531C

PDB ID 3mtt

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