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3n94

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==Crystal structure of human pituitary adenylate cyclase 1 Receptor-short N-terminal extracellular domain==
==Crystal structure of human pituitary adenylate cyclase 1 Receptor-short N-terminal extracellular domain==
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<StructureSection load='3n94' size='340' side='right' caption='[[3n94]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='3n94' size='340' side='right'caption='[[3n94]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3n94]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N94 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N94 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3n94]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N94 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N94 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MAL:MALTOSE'>MAL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">malE, b4034, JW3994, ADCYAP1R1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n94 OCA], [http://pdbe.org/3n94 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n94 RCSB], [http://www.ebi.ac.uk/pdbsum/3n94 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n94 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n94 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n94 OCA], [https://pdbe.org/3n94 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n94 RCSB], [https://www.ebi.ac.uk/pdbsum/3n94 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n94 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI]] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
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[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/PACR_HUMAN PACR_HUMAN] This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ecoli]]
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[[Category: Escherichia coli K-12]]
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[[Category: Kumar, S]]
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[[Category: Homo sapiens]]
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[[Category: Pioszak, A A]]
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[[Category: Large Structures]]
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[[Category: Swaminathan, K]]
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[[Category: Kumar S]]
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[[Category: Xu, H E]]
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[[Category: Pioszak AA]]
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[[Category: G-protein coupled receptor]]
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[[Category: Swaminathan K]]
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[[Category: Mbp fusion protein]]
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[[Category: Xu HE]]
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[[Category: Membrane receptor]]
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[[Category: Peptide hormone receptor]]
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Current revision

Crystal structure of human pituitary adenylate cyclase 1 Receptor-short N-terminal extracellular domain

PDB ID 3n94

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