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3n96
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==Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1== | ==Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1== | ||
| - | <StructureSection load='3n96' size='340' side='right' caption='[[3n96]], [[Resolution|resolution]] 2.75Å' scene=''> | + | <StructureSection load='3n96' size='340' side='right'caption='[[3n96]], [[Resolution|resolution]] 2.75Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3n96]] is a 8 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3n96]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N96 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene></td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n96 OCA], [https://pdbe.org/3n96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n96 RCSB], [https://www.ebi.ac.uk/pdbsum/3n96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n96 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/CRFR2_HUMAN CRFR2_HUMAN] G-protein coupled receptor for CRH (corticotropin-releasing factor), UCN (urocortin), UCN2 and UCN3. Has high affinity for UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Pal K]] |
| - | + | [[Category: Pioszak AA]] | |
| - | [[Category: | + | [[Category: Swaminathan K]] |
| - | [[Category: | + | [[Category: Xu HE]] |
| - | [[Category: | + | |
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Current revision
Crystal structure of human CRFR2 alpha extracellular domain in complex with Urocortin 1
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