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3neq

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==Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1==
==Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1==
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<StructureSection load='3neq' size='340' side='right' caption='[[3neq]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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<StructureSection load='3neq' size='340' side='right'caption='[[3neq]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3neq]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NEQ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3neq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dendroaspis_angusticeps Dendroaspis angusticeps]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NEQ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3fev|3fev]], [[2vlw|2vlw]], [[1ff4|1ff4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3neq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3neq OCA], [http://pdbe.org/3neq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3neq RCSB], [http://www.ebi.ac.uk/pdbsum/3neq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3neq ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3neq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3neq OCA], [https://pdbe.org/3neq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3neq RCSB], [https://www.ebi.ac.uk/pdbsum/3neq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3neq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/NXM11_DENAN NXM11_DENAN]] Binds irreversibly and specifically to M1 (CHRM1) muscarinic acetylcholine receptors, blocking further binding of antagonists and preventing the action of agonists.<ref>PMID:11562434</ref> <ref>PMID:10799315</ref>
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[https://www.uniprot.org/uniprot/3SIM7_DENAN 3SIM7_DENAN] Binds irreversibly and specifically to an allosteric site of the muscarinic acetylcholine M1 receptor (CHRM1).<ref>PMID:10799315</ref> <ref>PMID:11562434</ref> <ref>PMID:12488533</ref> <ref>PMID:21557730</ref> [https://www.uniprot.org/uniprot/3SIM1_DENAN 3SIM1_DENAN] Shows a non-competitive interaction with adrenergic and muscarinic receptors. Binds to alpha-2b (ADRA2B) (IC(50)=2.3 nM), alpha-1a (ADRA1A), alpha-1b (ADRA1B), and alpha-2c (ADRA2C) adrenergic receptors. Reversibly binds to M1 (CHRM1) muscarinic acetylcholine receptors, probably by interacting with the orthosteric site (PubMed:7778123, PubMed:12488533, PubMed:24793485). Also reveals a slightly weaker effect at M3 (CHRM3) and M4 (CHRM4) receptors (PubMed:7778123, PubMed:12488533, PubMed:24793485). The order of potency is ADRA2B>>CHRM1>ADRA1A>ADRA1B>ADRA2C/CHRM4 (PubMed:24793485).<ref>PMID:12488533</ref> <ref>PMID:21557730</ref> <ref>PMID:24793485</ref> <ref>PMID:7778123</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Fruchart-Gaillard, C]]
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[[Category: Dendroaspis angusticeps]]
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[[Category: Menez, A]]
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[[Category: Large Structures]]
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[[Category: Menez, R]]
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[[Category: Fruchart-Gaillard C]]
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[[Category: Mournier, G]]
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[[Category: Menez A]]
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[[Category: Servent, D]]
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[[Category: Menez R]]
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[[Category: Stura, E A]]
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[[Category: Mournier G]]
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[[Category: Chimeric muscarinic toxin]]
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[[Category: Servent D]]
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[[Category: Green mamba]]
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[[Category: Stura EA]]
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[[Category: Hm1-muscarinic receptor]]
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[[Category: Snake toxin]]
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[[Category: Toxin]]
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Current revision

Crystal structure of the chimeric muscarinic toxin MT7 with loop 3 from MT1

PDB ID 3neq

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