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3nsu

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==A Systematic Screen for Protein-Lipid Interactions in Saccharomyces cerevisiae==
==A Systematic Screen for Protein-Lipid Interactions in Saccharomyces cerevisiae==
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<StructureSection load='3nsu' size='340' side='right' caption='[[3nsu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3nsu' size='340' side='right'caption='[[3nsu]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3nsu]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NSU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3nsu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NSU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NSU FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1btk|1btk]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">LIT2, SLM1, YIL105C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsu OCA], [https://pdbe.org/3nsu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nsu RCSB], [https://www.ebi.ac.uk/pdbsum/3nsu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsu ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3nsu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nsu OCA], [http://pdbe.org/3nsu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3nsu RCSB], [http://www.ebi.ac.uk/pdbsum/3nsu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3nsu ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/SLM1_YEAST SLM1_YEAST]] Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.<ref>PMID:15372071</ref> <ref>PMID:15689497</ref> <ref>PMID:16959779</ref> <ref>PMID:16738335</ref>
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[https://www.uniprot.org/uniprot/SLM1_YEAST SLM1_YEAST] Together with SLM2, effector of the TORC2- and calcineurin-signaling pathways. Phosphorylated and activated by TORC2 under favorable growth conditions. Mediates actin polarization via inhibition of calcineurin-dependent transcription. Upon nutrient limitation or environmental stress, gets dephosphorylated by calcineurin. Dephosphorylation inhibits its interaction with TORC2, thereby antagonizing TORC2 signaling and mediating calcineurin-dependent actin depolarization. Also functions in heat-induced, calcineurin-mediated uracil permease (FUR4) endocytosis.<ref>PMID:15372071</ref> <ref>PMID:15689497</ref> <ref>PMID:16959779</ref> <ref>PMID:16738335</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Atcc 18824]]
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[[Category: Large Structures]]
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[[Category: Aguilar-Gurrieri, C]]
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[[Category: Saccharomyces cerevisiae]]
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[[Category: Fernandez-Tornero, C]]
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[[Category: Aguilar-Gurrieri C]]
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[[Category: Gallego, O]]
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[[Category: Fernandez-Tornero C]]
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[[Category: Gavin, A C]]
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[[Category: Gallego O]]
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[[Category: Muller, C]]
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[[Category: Gavin AC]]
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[[Category: Pleckstrin homology domain]]
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[[Category: Muller C]]
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[[Category: Signaling protein]]
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Current revision

A Systematic Screen for Protein-Lipid Interactions in Saccharomyces cerevisiae

PDB ID 3nsu

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