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3o3x

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[[Image:3o3x.jpg|left|200px]]
 
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==Crystal structure of gp41-5, a single-chain 5-helix-bundle based on HIV gp41==
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The line below this paragraph, containing "STRUCTURE_3o3x", creates the "Structure Box" on the page.
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<StructureSection load='3o3x' size='340' side='right'caption='[[3o3x]], [[Resolution|resolution]] 1.45&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o3x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O3X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.45&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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{{STRUCTURE_3o3x| PDB=3o3x | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o3x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3x OCA], [https://pdbe.org/3o3x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o3x RCSB], [https://www.ebi.ac.uk/pdbsum/3o3x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o3x ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Infection of cells by HIV depends upon profound structural rearrangements within the trimeric viral protein gp41. Critical to this process is the formation of a six-helix bundle in which a set of three N-terminal heptad repeat (NHR) helices assemble to form a core displaying long grooves that provide docking sites for three C-terminal heptad repeat (CHR) helices. We report experiments designed to discriminate between two alternative hypotheses regarding the source of affinity between individual CHR helices and the complementary groove: (1) affinity is dominated by interactions of a small cluster of side chains at one end of the CHR helix; or (2) affinity depends upon interactions distributed across the long CHR helix. We have employed two complementary experimental designs, and results from both favor the latter hypothesis.
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===Crystal structure of gp41-5, a single-chain 5-helix-bundle based on HIV gp41===
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Broad Distribution of Energetically Important Contacts across an Extended Protein Interface.,Johnson LM, Horne WS, Gellman SH J Am Chem Soc. 2011 Jul 6;133(26):10038-41. Epub 2011 Jun 14. PMID:21644542<ref>PMID:21644542</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3o3x" style="background-color:#fffaf0;"></div>
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==See Also==
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The line below this paragraph, {{ABSTRACT_PUBMED_21644542}}, adds the Publication Abstract to the page
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*[[Gp41 3D Structures|Gp41 3D Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21644542 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_21644542}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Large Structures]]
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[[3o3x]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3X OCA].
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==Reference==
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<ref group="xtra">PMID:021644542</ref><references group="xtra"/>
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[[Category: Synthetic construct]]
[[Category: Synthetic construct]]
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[[Category: Gellman, S H.]]
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[[Category: Gellman SH]]
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[[Category: Horne, W S.]]
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[[Category: Horne WS]]
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[[Category: Johnson, L M.]]
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[[Category: Johnson LM]]
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[[Category: Helix bundle]]
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[[Category: Mimic of hiv gp41]]
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[[Category: Viral protein]]
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Current revision

Crystal structure of gp41-5, a single-chain 5-helix-bundle based on HIV gp41

PDB ID 3o3x

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