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3o73

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Current revision (09:29, 6 September 2023) (edit) (undo)
 
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<StructureSection load='3o73' size='340' side='right'caption='[[3o73]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3o73' size='340' side='right'caption='[[3o73]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3o73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O73 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3o73]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O73 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O73 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=O73:5-[(4-AMINOBUTYL)AMINO]-1,2-DIMETHYL-3-[(4-NITROPHENOXY)METHYL]-1H-INDOLE-4,7-DIONE'>O73</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1qr2|1qr2]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=O73:5-[(4-AMINOBUTYL)AMINO]-1,2-DIMETHYL-3-[(4-NITROPHENOXY)METHYL]-1H-INDOLE-4,7-DIONE'>O73</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">NQO2, NMOR2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ribosyldihydronicotinamide_dehydrogenase_(quinone) Ribosyldihydronicotinamide dehydrogenase (quinone)], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.10.99.2 1.10.99.2] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o73 OCA], [https://pdbe.org/3o73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o73 RCSB], [https://www.ebi.ac.uk/pdbsum/3o73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o73 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o73 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o73 OCA], [https://pdbe.org/3o73 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o73 RCSB], [https://www.ebi.ac.uk/pdbsum/3o73 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o73 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN]] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Colucci, M A]]
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[[Category: Colucci MA]]
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[[Category: Dufour, M]]
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[[Category: De Matteis CI]]
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[[Category: Li, Y]]
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[[Category: Dufour M]]
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[[Category: Matteis, C I.De]]
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[[Category: Li Y]]
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[[Category: Moody, C J]]
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[[Category: Moody CJ]]
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[[Category: Ross, D]]
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[[Category: Ross D]]
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[[Category: Siegel, D]]
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[[Category: Siegel D]]
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[[Category: Yan, C]]
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[[Category: Yan C]]
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[[Category: Fad]]
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[[Category: Flavoprotein]]
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[[Category: Indolequinone mac627]]
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[[Category: Nqo2]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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[[Category: Quinone reductase 2]]
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Current revision

Crystal structure of quinone reductase 2 in complex with the indolequinone MAC627

PDB ID 3o73

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