3obx
From Proteopedia
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==Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 Gag P7A mutant peptide== | ==Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 Gag P7A mutant peptide== | ||
| - | <StructureSection load='3obx' size='340' side='right' caption='[[3obx]], [[Resolution|resolution]] 1.60Å' scene=''> | + | <StructureSection load='3obx' size='340' side='right'caption='[[3obx]], [[Resolution|resolution]] 1.60Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3obx]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3obx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OBX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OBX FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3obx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3obx OCA], [https://pdbe.org/3obx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3obx RCSB], [https://www.ebi.ac.uk/pdbsum/3obx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3obx ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TS101_HUMAN TS101_HUMAN] Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses.<ref>PMID:11916981</ref> <ref>PMID:17853893</ref> <ref>PMID:17556548</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 3obx" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[ | + | *[[Tumor susceptibility gene 101|Tumor susceptibility gene 101]] |
== References == | == References == | ||
<references/> | <references/> | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Human immunodeficiency virus 1]] |
| - | + | [[Category: Large Structures]] | |
| - | + | [[Category: Hurley JH]] | |
| - | [[Category: | + | [[Category: Im YJ]] |
| - | [[Category: | + | |
| - | [[Category: | + | |
Current revision
Crystal structure of the Tsg101 UEV domain in complex with a HIV-1 Gag P7A mutant peptide
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