3oc9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: {{Seed}} 200px <!-- The line below this paragraph, containing "STRUCTURE_3oc9", creates the "Structure Box" on the page. You may change the PDB parameter (which se...)
Current revision (09:34, 6 September 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3oc9.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of putative UDP-N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica==
-
The line below this paragraph, containing "STRUCTURE_3oc9", creates the "Structure Box" on the page.
+
<StructureSection load='3oc9' size='340' side='right'caption='[[3oc9]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3oc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Entamoeba_histolytica_HM-1:IMSS Entamoeba histolytica HM-1:IMSS]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OC9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_3oc9| PDB=3oc9 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oc9 OCA], [https://pdbe.org/3oc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oc9 RCSB], [https://www.ebi.ac.uk/pdbsum/3oc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oc9 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/C4M036_ENTH1 C4M036_ENTH1]
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oc/3oc9_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3oc9 ConSurf].
 +
<div style="clear:both"></div>
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Uridine diphosphate N-acetylglucosamine pyrophosphorylase (UAP) catalyzes the final step in the synthesis of UDP-GlcNAc, which is involved in cell-wall biogenesis in plants and fungi and in protein glycosylation. Small-molecule inhibitors have been developed against UAP from Trypanosoma brucei that target an allosteric pocket to provide selectivity over the human enzyme. A 1.8 A resolution crystal structure was determined of UAP from Entamoeba histolytica, an anaerobic parasitic protozoan that causes amoebic dysentery. Although E. histolytica UAP exhibits the same three-domain global architecture as other UAPs, it appears to lack three alpha-helices at the N-terminus and contains two amino acids in the allosteric pocket that make it appear more like the enzyme from the human host than that from the other parasite T. brucei. Thus, allosteric inhibitors of T. brucei UAP are unlikely to target Entamoeba UAPs.
-
===Crystal structure of putative UDP-N-acetylglucosamine pyrophosphate from Entamoeba histolytica===
+
Structure of uridine diphosphate N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica.,Edwards TE, Gardberg AS, Phan IQ, Zhang Y, Staker BL, Myler PJ, Lorimer DD Acta Crystallogr F Struct Biol Commun. 2015 May;71(Pt 5):560-5. doi:, 10.1107/S2053230X1500179X. Epub 2015 Apr 21. PMID:25945709<ref>PMID:25945709</ref>
-
 
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
==About this Structure==
+
</div>
-
3OC9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Entamoeba_histolytica Entamoeba histolytica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OC9 OCA].
+
<div class="pdbe-citations 3oc9" style="background-color:#fffaf0;"></div>
-
[[Category: Entamoeba histolytica]]
+
== References ==
-
[[Category: UDP-N-acetylglucosamine diphosphorylase]]
+
<references/>
-
[[Category: SSGCID, Seattle Structural Genomics Center for Infectious Disease.]]
+
__TOC__
-
[[Category: Amoebic dysentery]]
+
</StructureSection>
-
[[Category: Amoebic liver abscess]]
+
[[Category: Entamoeba histolytica HM-1:IMSS]]
-
[[Category: Anaerobic parasitic protozoan]]
+
[[Category: Large Structures]]
-
[[Category: Cyst]]
+
-
[[Category: Nucleotidyl transferase]]
+
-
[[Category: Seattle structural genomics center for infectious disease]]
+
-
[[Category: Ssgcid]]
+
-
[[Category: Structural genomic]]
+
-
[[Category: Transferase]]
+
-
[[Category: Udp-n-acetylglucosamine diphosphorylase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:52:55 2010''
+

Current revision

Crystal structure of putative UDP-N-acetylglucosamine pyrophosphorylase from Entamoeba histolytica

PDB ID 3oc9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3oc9"
Personal tools