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3oq3

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==Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor==
==Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor==
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<StructureSection load='3oq3' size='340' side='right' caption='[[3oq3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<StructureSection load='3oq3' size='340' side='right'caption='[[3oq3]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3oq3]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ectromelia_virus Ectromelia virus] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OQ3 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3oq3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ectromelia_virus_Moscow Ectromelia virus Moscow] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OQ3 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Ifna5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus]), C12R, EVM166 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12643 Ectromelia virus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oq3 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oq3 RCSB], [http://www.ebi.ac.uk/pdbsum/3oq3 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oq3 OCA], [https://pdbe.org/3oq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oq3 RCSB], [https://www.ebi.ac.uk/pdbsum/3oq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oq3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/IFNA5_MOUSE IFNA5_MOUSE]] Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
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[https://www.uniprot.org/uniprot/Q9JFS5_9POXV Q9JFS5_9POXV]
==See Also==
==See Also==
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*[[Interferon|Interferon]]
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*[[Interferon 3D structures|Interferon 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ectromelia virus]]
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[[Category: Ectromelia virus Moscow]]
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Structural genomic]]
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[[Category: Fremont DH]]
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[[Category: Fremont, D H]]
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[[Category: Lee CA]]
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[[Category: Lee, C A]]
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[[Category: Csgid]]
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[[Category: Cytokine decoy receptor]]
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[[Category: Cytokine-viral protein complex]]
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[[Category: Ectromelia]]
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[[Category: Extracellular]]
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[[Category: Ifn-alpha]]
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[[Category: Ifn-alpha/beta binding protein]]
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[[Category: Immunoglobulin domain]]
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[[Category: Immunoglobulin-like]]
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[[Category: Moscow strain]]
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[[Category: Mousepox virus]]
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[[Category: Secreted]]
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[[Category: Soluble a/b-ifnr]]
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[[Category: Type-1 interferon]]
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[[Category: Viral immune evasion]]
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[[Category: Virus/viral protein]]
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Current revision

Structural Basis of Type-I Interferon Sequestration by a Poxvirus Decoy Receptor

PDB ID 3oq3

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