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3p6a

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{{STRUCTURE_3p6a| PDB=3p6a | SCENE= }}
 
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===Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)===
 
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==Function==
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==Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)==
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[[http://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN]] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
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<StructureSection load='3p6a' size='340' side='right'caption='[[3p6a]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3p6a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P6A FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p6a OCA], [https://pdbe.org/3p6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p6a RCSB], [https://www.ebi.ac.uk/pdbsum/3p6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p6a ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ARHG1_HUMAN ARHG1_HUMAN] Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.<ref>PMID:8810315</ref> <ref>PMID:9641915</ref> <ref>PMID:9641916</ref> <ref>PMID:20098430</ref>
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==About this Structure==
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==See Also==
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[[3p6a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P6A OCA].
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*[[Rho guanine nucleotide exchange factor 3D structures|Rho guanine nucleotide exchange factor 3D structures]]
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== References ==
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==Reference==
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<references/>
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<references group="xtra"/><references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, Z.]]
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[[Category: Large Structures]]
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[[Category: Guo, L.]]
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[[Category: Chen Z]]
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[[Category: Sprang, S R.]]
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[[Category: Guo L]]
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[[Category: Sternweis, P C.]]
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[[Category: Sprang SR]]
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[[Category: Dh]]
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[[Category: Sternweis PC]]
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[[Category: Ph]]
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[[Category: Regulation of rhoa gtpase]]
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[[Category: Rho]]
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[[Category: Rhogef]]
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[[Category: Signaling protein]]
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Current revision

Crystal Structure of the DH/PH domains of p115-RhoGEF (R399E mutant)

PDB ID 3p6a

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