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3p8w

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==Crystal Structure Analysis of R29M/E81M double mutant of human CLIC1==
==Crystal Structure Analysis of R29M/E81M double mutant of human CLIC1==
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<StructureSection load='3p8w' size='340' side='right' caption='[[3p8w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3p8w' size='340' side='right'caption='[[3p8w]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p8w]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P8W FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p8w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P8W FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3p90|3p90]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CLIC1, G6, NCC27 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8w OCA], [https://pdbe.org/3p8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p8w RCSB], [https://www.ebi.ac.uk/pdbsum/3p8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p8w ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p8w RCSB], [http://www.ebi.ac.uk/pdbsum/3p8w PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN]] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
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[https://www.uniprot.org/uniprot/CLIC1_HUMAN CLIC1_HUMAN] Can insert into membranes and form chloride ion channels. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Involved in regulation of the cell cycle.<ref>PMID:9139710</ref> <ref>PMID:10834939</ref> <ref>PMID:11195932</ref> <ref>PMID:11940526</ref> <ref>PMID:11978800</ref> <ref>PMID:11551966</ref> <ref>PMID:14613939</ref>
==See Also==
==See Also==
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*[[Ion channels|Ion channels]]
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*[[Ion channels 3D structures|Ion channels 3D structures]]
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Achilonu, I A]]
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[[Category: Large Structures]]
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[[Category: Dirr, H W]]
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[[Category: Achilonu IA]]
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[[Category: Fanucchi, S]]
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[[Category: Dirr HW]]
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[[Category: Fernandes, M A]]
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[[Category: Fanucchi S]]
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[[Category: Silva, D A.Legg-E]]
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[[Category: Fernandes MA]]
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[[Category: Clic]]
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[[Category: Legg-E'Silva DA]]
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[[Category: Glutathione transferase]]
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[[Category: Ion channel]]
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[[Category: Salt bridge]]
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[[Category: Thioredoxin]]
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[[Category: Transport protein]]
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Current revision

Crystal Structure Analysis of R29M/E81M double mutant of human CLIC1

PDB ID 3p8w

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