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3p99

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==Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol==
==Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol==
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<StructureSection load='3p99' size='340' side='right' caption='[[3p99]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='3p99' size='340' side='right'caption='[[3p99]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3p99]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P99 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3P99 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3p99]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P99 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P99 FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LNP:(3ALPHA,9BETA,10ALPHA,13ALPHA)-30-CYCLOPROPYLIDENELANOST-7-EN-3-OL'>LNP</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3g1q|3g1q]], [[3gw9|3gw9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=LNP:(3ALPHA,9BETA,10ALPHA,13ALPHA)-30-CYCLOPROPYLIDENELANOST-7-EN-3-OL'>LNP</scene></td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CYP51, Tb11.02.4080 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5691 Trypanosoma brucei])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p99 OCA], [https://pdbe.org/3p99 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p99 RCSB], [https://www.ebi.ac.uk/pdbsum/3p99 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p99 ProSAT]</span></td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Sterol_14-demethylase Sterol 14-demethylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.14.13.70 1.14.13.70] </span></td></tr>
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</table>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3p99 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p99 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3p99 RCSB], [http://www.ebi.ac.uk/pdbsum/3p99 PDBsum]</span></td></tr>
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== Function ==
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<table>
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[https://www.uniprot.org/uniprot/Q385E8_TRYB2 Q385E8_TRYB2]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3p99" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Sterol 14-demethylase]]
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[[Category: Large Structures]]
[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Hargrove, T Y.]]
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[[Category: Hargrove TY]]
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[[Category: Lepesheva, G I.]]
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[[Category: Lepesheva GI]]
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[[Category: Waterman, M R]]
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[[Category: Waterman MR]]
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[[Category: Wawrzak, Z.]]
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[[Category: Wawrzak Z]]
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[[Category: Cyp51]]
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[[Category: Cytochrome p450 fold/sterol 14-alpha demethylase]]
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[[Category: Endoplasmic reticulum]]
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[[Category: Hemoprotein]]
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[[Category: Membrane]]
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[[Category: Monooxygenase]]
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[[Category: Oxidoreductase]]
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[[Category: Sterol biosynthesis]]
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Current revision

Sterol 14alpha-demethylase (CYP51) from Trypanosoma brucei in complex with delta7-14alpha-methylene-cyclopropyl-dihydrolanosterol

PDB ID 3p99

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