This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3pio

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:55, 6 September 2023) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3pio.jpg|left|200px]]
 
-
<!--
+
==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
-
The line below this paragraph, containing "STRUCTURE_3pio", creates the "Structure Box" on the page.
+
<StructureSection load='3pio' size='340' side='right'caption='[[3pio]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3pio]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PIO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2473&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-
{{STRUCTURE_3pio| PDB=3pio | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pio OCA], [https://pdbe.org/3pio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pio RCSB], [https://www.ebi.ac.uk/pdbsum/3pio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pio ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RL19_DEIRA RL19_DEIRA] This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity). Binds the 23S rRNA.[HAMAP-Rule:MF_00402]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The structures of the large ribosomal subunit of Deinococcus radiodurans (D50S) in complex with the antibiotic lankamycin (3.2 A) and a double antibiotic complex of lankamycin and lankacidin C (3.45 A) have been determined, in continuation of previous crystallographic studies on lankacidin-D50S complex. These two drugs have been previously reported to inhibit ribosomal function with mild synergistic effect. Lankamycin, a member of the macrolide family, binds in a similar manner to erythromycin. However, when in complex with lankacidin, lankamycin is located so that it can form interactions with lankacidin in the adjacent ribosomal binding site. When compared to the well-documented synergistic antibiotics, Streptogramins A and B, the pair of lankacidin and lankamycin bind in similar sites, the peptidyl transferase center and nascent peptide exit tunnel, respectively. Herein, we discuss the structural basis for antibiotic synergism and highlight the key factors involved in ribosomal inhibition.
-
===Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit===
+
Crystal structure of the synergistic antibiotic pair, lankamycin and lankacidin, in complex with the large ribosomal subunit.,Belousoff MJ, Shapira T, Bashan A, Zimmerman E, Rozenberg H, Arakawa K, Kinashi H, Yonath A Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2717-22. Epub 2011 Jan 31. PMID:21282615<ref>PMID:21282615</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3pio" style="background-color:#fffaf0;"></div>
-
<!--
+
==See Also==
-
The line below this paragraph, {{ABSTRACT_PUBMED_21282615}}, adds the Publication Abstract to the page
+
*[[Ribosome 3D structures|Ribosome 3D structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 21282615 is the PubMed ID number.
+
== References ==
-
-->
+
<references/>
-
{{ABSTRACT_PUBMED_21282615}}
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
[[Category: Deinococcus radiodurans]]
-
[[3pio]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermomicrobium_roseum Thermomicrobium roseum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIO OCA].
+
[[Category: Large Structures]]
-
 
+
[[Category: Arakawa K]]
-
==Reference==
+
[[Category: Bashan A]]
-
<ref group="xtra">PMID:21282615</ref><references group="xtra"/>
+
[[Category: Belousoff MJ]]
-
[[Category: Thermomicrobium roseum]]
+
[[Category: Kinashi H]]
-
[[Category: Arakawa, K.]]
+
[[Category: Rozenberg H]]
-
[[Category: Bashan, A.]]
+
[[Category: Shapira T]]
-
[[Category: Belousoff, M J.]]
+
[[Category: Yonath A]]
-
[[Category: H., Rozenberg.]]
+
[[Category: Zimmerman E]]
-
[[Category: Kinashi, H.]]
+
-
[[Category: Shapira, T.]]
+
-
[[Category: Yonath, A.]]
+
-
[[Category: Zimmerman, E.]]
+

Current revision

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit

PDB ID 3pio

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3pio"
Personal tools