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3pio

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==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
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<StructureSection load='3pio' size='340' side='right' caption='[[3pio]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
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<StructureSection load='3pio' size='340' side='right'caption='[[3pio]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pio]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PIO FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pio]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PIO FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2473&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zjr|2zjr]], [[1nkw|1nkw]], [[1sm1|1sm1]], [[3jq4|3jq4]], [[1yi2|1yi2]], [[3pip|3pip]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pio OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pio RCSB], [http://www.ebi.ac.uk/pdbsum/3pio PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pio OCA], [https://pdbe.org/3pio PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pio RCSB], [https://www.ebi.ac.uk/pdbsum/3pio PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pio ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL19_DEIRA RL19_DEIRA] This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity). Binds the 23S rRNA.[HAMAP-Rule:MF_00402]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3pio" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Deinococcus radiodurans r1]]
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[[Category: Large Structures]]
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[[Category: Arakawa, K]]
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[[Category: Arakawa K]]
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[[Category: Bashan, A]]
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[[Category: Bashan A]]
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[[Category: Belousoff, M J]]
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[[Category: Belousoff MJ]]
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[[Category: H., Rozenberg]]
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[[Category: Kinashi H]]
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[[Category: Kinashi, H]]
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[[Category: Rozenberg H]]
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[[Category: Shapira, T]]
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[[Category: Shapira T]]
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[[Category: Yonath, A]]
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[[Category: Yonath A]]
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[[Category: Zimmerman, E]]
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[[Category: Zimmerman E]]
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[[Category: Lankacidin]]
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[[Category: Lankamycin]]
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[[Category: Large ribosomal subunit]]
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[[Category: Macrolide]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Ribosome-antibiotic complex]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Trna-binding]]
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Current revision

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit

PDB ID 3pio

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