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3pip

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==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
==Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit==
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<StructureSection load='3pip' size='340' side='right' caption='[[3pip]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
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<StructureSection load='3pip' size='340' side='right'caption='[[3pip]], [[Resolution|resolution]] 3.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3pip]] is a 30 chain structure with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [http://en.wikipedia.org/wiki/Deinococcus_radiodurans_r1 Deinococcus radiodurans r1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3PIP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3pip]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans] and [https://en.wikipedia.org/wiki/Deinococcus_radiodurans_R1 Deinococcus radiodurans R1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PIP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PIP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LC2:N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-DIHYDROXY-1,4,10,19-TETRAMETHYL-17,18-DIOXO-16-OXABICYCLO[13.2.2]NONADECA-3,5,9,11-TETRAEN-2-YL]-2-OXOPROPANAMIDE'>LC2</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.45&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2zjr|2zjr]], [[1nkw|1nkw]], [[1sm1|1sm1]], [[3jq4|3jq4]], [[1yi2|1yi2]], [[3pio|3pio]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=LC2:N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7,13-DIHYDROXY-1,4,10,19-TETRAMETHYL-17,18-DIOXO-16-OXABICYCLO[13.2.2]NONADECA-3,5,9,11-TETRAEN-2-YL]-2-OXOPROPANAMIDE'>LC2</scene>, <scene name='pdbligand=LMA:LANKAMYCIN'>LMA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3pip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pip OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3pip RCSB], [http://www.ebi.ac.uk/pdbsum/3pip PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pip FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pip OCA], [https://pdbe.org/3pip PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pip RCSB], [https://www.ebi.ac.uk/pdbsum/3pip PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pip ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RL2_DEIRA RL2_DEIRA] One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome (By similarity).[HAMAP-Rule:MF_01320_B]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3pip" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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</StructureSection>
</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Deinococcus radiodurans r1]]
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[[Category: Deinococcus radiodurans R1]]
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[[Category: Bashan, A]]
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[[Category: Large Structures]]
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[[Category: Belousoff, M J]]
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[[Category: Bashan A]]
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[[Category: Kinashi, H]]
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[[Category: Belousoff MJ]]
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[[Category: Rozenberg, H]]
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[[Category: Kinashi H]]
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[[Category: Shapira, T]]
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[[Category: Rozenberg H]]
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[[Category: Yonath, A]]
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[[Category: Shapira T]]
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[[Category: Zimmerman, E]]
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[[Category: Yonath A]]
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[[Category: Lankacidin]]
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[[Category: Zimmerman E]]
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[[Category: Lankamycin]]
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[[Category: Large ribosomal subunit]]
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[[Category: Macrolide]]
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[[Category: Ribonucleoprotein]]
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[[Category: Ribosomal protein]]
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[[Category: Ribosome]]
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[[Category: Ribosome-antibiotic complex]]
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[[Category: Rna-binding]]
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[[Category: Rrna-binding]]
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[[Category: Trna-binding]]
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Current revision

Crystal structure of the synergistic antibiotic pair lankamycin and lankacidin in complex with the large ribosomal subunit

PDB ID 3pip

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