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3pon

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[[Image:3pon.jpg|left|200px]]
 
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==Crystal structure of MBL collagen-like peptide==
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The line below this paragraph, containing "STRUCTURE_3pon", creates the "Structure Box" on the page.
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<StructureSection load='3pon' size='340' side='right'caption='[[3pon]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3pon]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PON OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PON FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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{{STRUCTURE_3pon| PDB=3pon | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pon FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pon OCA], [https://pdbe.org/3pon PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pon RCSB], [https://www.ebi.ac.uk/pdbsum/3pon PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pon ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Complement activation contributes directly to health and disease. It neutralizes pathogens and stimulates immune processes. Defects lead to immunodeficiency and autoimmune diseases, whereas inappropriate activation causes self-damage. In the lectin and classical pathways, complement is triggered upon recognition of a pathogen by an activating complex. Here we present the first structure of such a complex in the form of the collagen-like domain of mannan-binding lectin (MBL) and the binding domain of its associated protease (MASP-1/-3). The collagen binds within a groove using a pivotal lysine side chain that interacts with Ca(2+)-coordinating residues, revealing the essential role of Ca(2+). This mode of binding is prototypic for all activating complexes of the lectin and classical pathways, and suggests a general mechanism for the global changes that drive activation. The structural insights reveal a new focus for inhibitors and we have validated this concept by targeting the binding pocket of the MASP.
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===Crystal structure of MBL collagen-like peptide===
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Structural Basis of Mannan-Binding Lectin Recognition by Its Associated Serine Protease MASP-1: Implications for Complement Activation.,Gingras AR, Girija UV, Keeble AH, Panchal R, Mitchell DA, Moody PC, Wallis R Structure. 2011 Nov 9;19(11):1635-43. PMID:22078562<ref>PMID:22078562</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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==About this Structure==
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</div>
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[[3pon]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PON OCA].
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<div class="pdbe-citations 3pon" style="background-color:#fffaf0;"></div>
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[[Category: Gingras, A R.]]
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== References ==
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[[Category: Moody, P C.E.]]
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<references/>
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[[Category: Wallis, R.]]
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__TOC__
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[[Category: Bloodstream]]
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</StructureSection>
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[[Category: Collagen peptide]]
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[[Category: Large Structures]]
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[[Category: Complement protein]]
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[[Category: Gingras AR]]
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[[Category: Lectin pathway of complement]]
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[[Category: Moody PCE]]
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[[Category: Mbl collagen-like region]]
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[[Category: Wallis R]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of MBL collagen-like peptide

PDB ID 3pon

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