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3pry

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[[Image:3pry.png|left|200px]]
 
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{{STRUCTURE_3pry| PDB=3pry | SCENE= }}
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==Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution==
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<StructureSection load='3pry' size='340' side='right'caption='[[3pry]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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===Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3pry]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PRY FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[3pry]] is a 3 chain structure of [[Heat Shock Proteins]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PRY OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pry OCA], [https://pdbe.org/3pry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pry RCSB], [https://www.ebi.ac.uk/pdbsum/3pry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pry ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HS90B_HUMAN HS90B_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:16478993</ref> <ref>PMID:19696785</ref>
==See Also==
==See Also==
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Large Structures]]
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[[Category: Ayinampudi, V.]]
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[[Category: Arrowsmith CH]]
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[[Category: Berridge, G.]]
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[[Category: Ayinampudi V]]
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[[Category: Bountra, C.]]
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[[Category: Berridge G]]
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[[Category: Bullock, A.]]
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[[Category: Bountra C]]
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[[Category: Chaikuad, A.]]
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[[Category: Bullock A]]
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[[Category: Che, K H.]]
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[[Category: Chaikuad A]]
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[[Category: Cooper, C D.O.]]
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[[Category: Che KH]]
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[[Category: Delft, F von.]]
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[[Category: Cooper CDO]]
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[[Category: Edwards, A.]]
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[[Category: Edwards A]]
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[[Category: Fedorov, O.]]
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[[Category: Fedorov O]]
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[[Category: Keates, T.]]
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[[Category: Keates T]]
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[[Category: Krojer, T.]]
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[[Category: Krojer T]]
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[[Category: Muniz, J R.C.]]
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[[Category: Muniz JRC]]
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[[Category: Phillips, C.]]
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[[Category: Phillips C]]
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[[Category: Pilka, E.]]
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[[Category: Pilka E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sharpe TD]]
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[[Category: Sharpe, T D.]]
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[[Category: Thangaratnarajah C]]
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[[Category: Thangaratnarajah, C.]]
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[[Category: Vollmar M]]
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[[Category: Vollmar, M.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Yue WW]]
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[[Category: Yue, W W.]]
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[[Category: Zimmermann T]]
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[[Category: Zimmermann, T.]]
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[[Category: Von Delft F]]
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[[Category: Chaperone]]
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[[Category: Heat shock protein]]
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[[Category: Hsp90b]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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Current revision

Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution

PDB ID 3pry

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