This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3pux

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:01, 6 September 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3pux.jpg|left|200px]]
 
-
<!--
+
==Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3==
-
The line below this paragraph, containing "STRUCTURE_3pux", creates the "Structure Box" on the page.
+
<StructureSection load='3pux' size='340' side='right'caption='[[3pux]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3pux]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PUX FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=BEF:BERYLLIUM+TRIFLUORIDE+ION'>BEF</scene>, <scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PGV:(1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL+(11E)-OCTADEC-11-ENOATE'>PGV</scene>, <scene name='pdbligand=PRD_900001:alpha-maltose'>PRD_900001</scene>, <scene name='pdbligand=UMQ:UNDECYL-MALTOSIDE'>UMQ</scene></td></tr>
-
{{STRUCTURE_3pux| PDB=3pux | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pux FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pux OCA], [https://pdbe.org/3pux PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pux RCSB], [https://www.ebi.ac.uk/pdbsum/3pux PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pux ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
ATP-binding cassette transporters are powered by ATP, but the mechanism by which these transporters hydrolyze ATP is unclear. In this study, four crystal structures of the full-length wild-type maltose transporter, stabilized by adenosine 5'-(beta,gamma-imido)triphosphate or ADP in conjunction with phosphate analogs , , or , were determined to 2.2- to 2.4-A resolution. These structures led to the assignment of two enzymatic states during ATP hydrolysis and demonstrate specific functional roles of highly conserved residues in the nucleotide-binding domain, suggesting that ATP-binding cassette transporters catalyze ATP hydrolysis via a general base mechanism.
-
===Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3===
+
Snapshots of the maltose transporter during ATP hydrolysis.,Oldham ML, Chen J Proc Natl Acad Sci U S A. 2011 Aug 8. PMID:21825153<ref>PMID:21825153</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 3pux" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[3pux]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PUX OCA].
+
*[[Maltose-binding protein 3D structures|Maltose-binding protein 3D structures]]
-
[[Category: Escherichia coli]]
+
== References ==
-
[[Category: Maltose-transporting ATPase]]
+
<references/>
-
[[Category: Chen, J.]]
+
__TOC__
-
[[Category: Oldham, M L.]]
+
</StructureSection>
-
[[Category: Abc transporter]]
+
[[Category: Escherichia coli K-12]]
-
[[Category: Atp binding]]
+
[[Category: Large Structures]]
-
[[Category: Atp binding cassette]]
+
[[Category: Chen J]]
-
[[Category: Atpase]]
+
[[Category: Oldham ML]]
-
[[Category: Hydrolase-transport protein complex]]
+
-
[[Category: Importer]]
+
-
[[Category: Maltodextrin binding]]
+
-
[[Category: Nucleotide binding domain]]
+
-
[[Category: Substrate binding protein]]
+
-
[[Category: Transmembrane integral membrane]]
+

Current revision

Crystal Structure of an outward-facing MBP-Maltose transporter complex bound to ADP-BeF3

PDB ID 3pux

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3pux"
Personal tools