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8hul
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8hul is ON HOLD Authors: Description: Category: Unreleased Structures) |
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| - | '''Unreleased structure''' | ||
| - | + | ==X-ray structure of human PPAR delta ligand binding domain-lanifibranor co-crystals obtained by co-crystallization== | |
| + | <StructureSection load='8hul' size='340' side='right'caption='[[8hul]], [[Resolution|resolution]] 2.46Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[8hul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HUL FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.461Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJB:4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloro-indol-2-yl]butanoic+acid'>BJB</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hul OCA], [https://pdbe.org/8hul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hul RCSB], [https://www.ebi.ac.uk/pdbsum/8hul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hul ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PPARD_HUMAN PPARD_HUMAN] Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.<ref>PMID:1333051</ref> <ref>PMID:15604518</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Honda A]] | ||
| + | [[Category: Ishii I]] | ||
| + | [[Category: Kamata S]] | ||
| + | [[Category: Machida Y]] | ||
| + | [[Category: Masuda R]] | ||
| + | [[Category: Oyama T]] | ||
| + | [[Category: Shiiyama Y]] | ||
| + | [[Category: Uchii K]] | ||
Current revision
X-ray structure of human PPAR delta ligand binding domain-lanifibranor co-crystals obtained by co-crystallization
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Categories: Homo sapiens | Large Structures | Honda A | Ishii I | Kamata S | Machida Y | Masuda R | Oyama T | Shiiyama Y | Uchii K
