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2ck5

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[[Image:2ck5.jpg|left|200px]]
 
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{{Structure
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==Solution structure of Delta 1-7 aOSK1==
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|PDB= 2ck5 |SIZE=350|CAPTION= <scene name='initialview01'>2ck5</scene>
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<StructureSection load='2ck5' size='340' side='right'caption='[[2ck5]]' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2ck5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Orthochirus_scrobiculosus Orthochirus scrobiculosus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CK5 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ck5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ck5 OCA], [https://pdbe.org/2ck5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ck5 RCSB], [https://www.ebi.ac.uk/pdbsum/2ck5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ck5 ProSAT]</span></td></tr>
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}}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/KAX37_ORTSC KAX37_ORTSC] Blocks voltage-gated potassium channels Kv1.1/KCNA1 (IC(50)=0.6nM), Kv1.2/KCNA2 (IC(50)=5.4nM), Kv1.3/KCNA3 (IC(50)=0.014nM) potently, and moderately block intermediate conductance calcium-activated potassium channels KCa3.1/KCNN4 (IC(50)=225nM). At high concentration (2 mM), is also active on Kv1.6/KCNA6 and Shaker IR.[REFERENCE:1]<ref>PMID:15588251</ref>
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'''SOLUTION STRUCTURE OF DELTA 1-7 AOSK1'''
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==See Also==
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*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2CK5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CK5 OCA].
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Alphonse, S.]]
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[[Category: Large Structures]]
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[[Category: Bernard, C.]]
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[[Category: Orthochirus scrobiculosus]]
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[[Category: Darbon, H.]]
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[[Category: Alphonse S]]
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[[Category: Mouhat, S.]]
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[[Category: Bernard C]]
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[[Category: Sabatier, J M.]]
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[[Category: Darbon H]]
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[[Category: ion channel blocker]]
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[[Category: Mouhat S]]
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[[Category: ion channel inhibitor]]
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[[Category: Sabatier JM]]
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[[Category: ionic channel inhibitor]]
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[[Category: neurotoxin]]
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[[Category: osk1]]
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[[Category: potassium channel inhibitor]]
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[[Category: scorpio toxin]]
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[[Category: toxin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 16:16:26 2008''
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Current revision

Solution structure of Delta 1-7 aOSK1

PDB ID 2ck5

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OCA

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