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| | <StructureSection load='5ivx' size='340' side='right'caption='[[5ivx]], [[Resolution|resolution]] 2.10Å' scene=''> | | <StructureSection load='5ivx' size='340' side='right'caption='[[5ivx]], [[Resolution|resolution]] 2.10Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5ivx]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVX OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=5IVX FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5ivx]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5IVX FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5iw1|5iw1]]</td></tr> | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=5ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivx OCA], [http://pdbe.org/5ivx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ivx RCSB], [http://www.ebi.ac.uk/pdbsum/5ivx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivx ProSAT]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ivx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ivx OCA], [https://pdbe.org/5ivx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ivx RCSB], [https://www.ebi.ac.uk/pdbsum/5ivx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ivx ProSAT]</span></td></tr> |
| | </table> | | </table> |
| | == Function == | | == Function == |
| - | [[http://www.uniprot.org/uniprot/HA12_MOUSE HA12_MOUSE]] Involved in the presentation of foreign antigens to the immune system. [[http://www.uniprot.org/uniprot/B2MG_MOUSE B2MG_MOUSE]] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. | + | [https://www.uniprot.org/uniprot/HA12_MOUSE HA12_MOUSE] Involved in the presentation of foreign antigens to the immune system. |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Jiang, J]] | + | [[Category: Mus musculus]] |
| - | [[Category: Margulies, D]] | + | [[Category: Jiang J]] |
| - | [[Category: Natarajan, K]] | + | [[Category: Margulies D]] |
| - | [[Category: B4 2.3]] | + | [[Category: Natarajan K]] |
| - | [[Category: B423]]
| + | |
| - | [[Category: H-2dd]]
| + | |
| - | [[Category: H2-dd]]
| + | |
| - | [[Category: Human immunodeficiency virus]]
| + | |
| - | [[Category: Immune response]]
| + | |
| - | [[Category: Immune system]]
| + | |
| - | [[Category: Major histompatibility complex class i]]
| + | |
| - | [[Category: Mhc-i]]
| + | |
| - | [[Category: Molecular recognition]]
| + | |
| - | [[Category: T-cell receptor]]
| + | |
| - | [[Category: Tcr]]
| + | |
| - | [[Category: Viral immunoevasion]]
| + | |
| Structural highlights
Function
HA12_MOUSE Involved in the presentation of foreign antigens to the immune system.
Publication Abstract from PubMed
The molecular mechanism through which the interaction of a clonotypic alphabeta T-cell receptor (TCR) with a peptide-loaded major histocompatibility complex (p/MHC) leads to T-cell activation is not yet fully understood. Here we exploit a high-affinity TCR (B4.2.3) to examine the structural changes that accompany binding to its p/MHC ligand (P18-I10/H2-Dd). In addition to conformational changes in complementarity-determining regions (CDRs) of the TCR seen in comparison of unliganded and bound X-ray structures, NMR characterization of the TCR beta-chain dynamics reveals significant chemical shift effects in sites removed from the MHC-binding site. Remodelling of electrostatic interactions near the Cbeta H3 helix at the membrane-proximal face of the TCR, a region implicated in interactions with the CD3 co-receptor, suggests a possible role for an allosteric mechanism in TCR signalling. The contribution of these TCR residues to signal transduction is supported by mutagenesis and T-cell functional assays.
An allosteric site in the T-cell receptor Cbeta domain plays a critical signalling role.,Natarajan K, McShan AC, Jiang J, Kumirov VK, Wang R, Zhao H, Schuck P, Tilahun ME, Boyd LF, Ying J, Bax A, Margulies DH, Sgourakis NG Nat Commun. 2017 May 16;8:15260. doi: 10.1038/ncomms15260. PMID:28508865[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Natarajan K, McShan AC, Jiang J, Kumirov VK, Wang R, Zhao H, Schuck P, Tilahun ME, Boyd LF, Ying J, Bax A, Margulies DH, Sgourakis NG. An allosteric site in the T-cell receptor Cbeta domain plays a critical signalling role. Nat Commun. 2017 May 16;8:15260. doi: 10.1038/ncomms15260. PMID:28508865 doi:http://dx.doi.org/10.1038/ncomms15260
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