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5j1n

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==Lassa virus L protein cap-snatching endonuclease. Bound to one manganese ion==
==Lassa virus L protein cap-snatching endonuclease. Bound to one manganese ion==
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<StructureSection load='5j1n' size='340' side='right' caption='[[5j1n]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
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<StructureSection load='5j1n' size='340' side='right'caption='[[5j1n]], [[Resolution|resolution]] 1.09&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j1n]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1N OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J1N FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j1n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lassa_mammarenavirus Lassa mammarenavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J1N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J1N FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN3:MANGANESE+(III)+ION'>MN3</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.09&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5izh|5izh]], [[5ize|5ize]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN3:MANGANESE+(III)+ION'>MN3</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/RNA-directed_RNA_polymerase RNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.48 2.7.7.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1n OCA], [https://pdbe.org/5j1n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j1n RCSB], [https://www.ebi.ac.uk/pdbsum/5j1n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1n ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j1n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j1n OCA], [http://pdbe.org/5j1n PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j1n RCSB], [http://www.ebi.ac.uk/pdbsum/5j1n PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j1n ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q6GWS6_9VIRU Q6GWS6_9VIRU]] RNA-dependent RNA polymerase which is responsible for replication and transcription of the viral RNA genome. During transcription, synthesizes 4 subgenomic RNAs, and assures their capping by a cap-snatching mechanism, in which cellular capped pre-mRNA are used to generate primers for viral transcription. The 3'-end of subgenomic mRNAs molecules are heterogeneous and not polyadenylated. The replicase function is to direct synthesis of antigenomic and genomic RNA which are encapsidated and non capped. As a consequence of the use of the same enzyme for both transcription and replication, these mechanisms need to be well coordinated. These processes may be regulated by proteins N and Z in a dose-dependent manner.[PIRNR:PIRNR000836]
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[https://www.uniprot.org/uniprot/L_LASV L_LASV]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5j1n" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5j1n" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: RNA-directed RNA polymerase]]
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[[Category: Large Structures]]
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[[Category: Cusack, S]]
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[[Category: Lassa mammarenavirus]]
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[[Category: Reguera, J]]
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[[Category: Cusack S]]
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[[Category: Cap-snatching nuclease lassa transcription]]
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[[Category: Reguera J]]
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[[Category: Transferase]]
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Current revision

Lassa virus L protein cap-snatching endonuclease. Bound to one manganese ion

PDB ID 5j1n

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