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5j26
From Proteopedia
(Difference between revisions)
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==Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant== | ==Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant== | ||
| - | <StructureSection load='5j26' size='340' side='right' caption='[[5j26]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='5j26' size='340' side='right'caption='[[5j26]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5j26]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5j26]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J26 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J26 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5047Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j26 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j26 OCA], [https://pdbe.org/5j26 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j26 RCSB], [https://www.ebi.ac.uk/pdbsum/5j26 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j26 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Note=A chromosomal aberration involving TP53BP1 is found in a form of myeloproliferative disorder chronic with eosinophilia. Translocation t(5;15)(q33;q22) with PDGFRB creating a TP53BP1-PDGFRB fusion protein. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TP53B_HUMAN TP53B_HUMAN] Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.<ref>PMID:12364621</ref> <ref>PMID:17190600</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Canny | + | [[Category: Large Structures]] |
| - | [[Category: Durocher | + | [[Category: Canny M]] |
| - | [[Category: Juang | + | [[Category: Durocher D]] |
| - | [[Category: Sicheri | + | [[Category: Juang YC]] |
| - | [[Category: Wan | + | [[Category: Sicheri F]] |
| - | + | [[Category: Wan L]] | |
| - | + | ||
Current revision
Crystal structure of a 53BP1 Tudor domain in complex with a ubiquitin variant
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Categories: Homo sapiens | Large Structures | Canny M | Durocher D | Juang YC | Sicheri F | Wan L
