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5j5r

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==M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718==
==M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718==
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<StructureSection load='5j5r' size='340' side='right' caption='[[5j5r]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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<StructureSection load='5j5r' size='340' side='right'caption='[[5j5r]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j5r]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J5R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j5r]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycolicibacterium_thermoresistibile_ATCC_19527 Mycolicibacterium thermoresistibile ATCC 19527]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J5R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6G1:CYCLOHEXYL{4-[(ISOQUINOLIN-5-YL)SULFONYL]PIPERAZIN-1-YL}METHANONE'>6G1</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6G1:CYCLOHEXYL{4-[(ISOQUINOLIN-5-YL)SULFONYL]PIPERAZIN-1-YL}METHANONE'>6G1</scene>, <scene name='pdbligand=IMP:INOSINIC+ACID'>IMP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j5r OCA], [http://pdbe.org/5j5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j5r RCSB], [http://www.ebi.ac.uk/pdbsum/5j5r PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j5r ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j5r OCA], [https://pdbe.org/5j5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j5r RCSB], [https://www.ebi.ac.uk/pdbsum/5j5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j5r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/G7CNL4_MYCT3 G7CNL4_MYCT3]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
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[https://www.uniprot.org/uniprot/G7CNL4_MYCT3 G7CNL4_MYCT3] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.[HAMAP-Rule:MF_01964]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
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*[[Inosine monophosphate dehydrogenase|Inosine monophosphate dehydrogenase]]
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*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: IMP dehydrogenase]]
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[[Category: Large Structures]]
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[[Category: Ascher, D B]]
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[[Category: Mycolicibacterium thermoresistibile ATCC 19527]]
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[[Category: Blundell, T L]]
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[[Category: Ascher DB]]
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[[Category: Pacitto, A]]
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[[Category: Blundell TL]]
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[[Category: Guab2]]
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[[Category: Pacitto A]]
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[[Category: Impdh]]
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[[Category: Inhibitor]]
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[[Category: Mycobacterium]]
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[[Category: Oxidoreductase]]
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Current revision

M. thermoresistible GuaB2 delta-CBS in complex with inhibitor VCC234718

PDB ID 5j5r

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