This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


5j63

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:50, 6 September 2023) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Crystal Structure of the N-terminal N-formyltransferase Domain (residues 1-306) of Escherichia coli Arna in Complex with UDP-Ara4N and Folinic Acid==
==Crystal Structure of the N-terminal N-formyltransferase Domain (residues 1-306) of Escherichia coli Arna in Complex with UDP-Ara4N and Folinic Acid==
-
<StructureSection load='5j63' size='340' side='right' caption='[[5j63]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+
<StructureSection load='5j63' size='340' side='right'caption='[[5j63]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[5j63]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_h736 Escherichia coli h736]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J63 FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[5j63]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_H736 Escherichia coli H736]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J63 FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FNX:(4AS,6S)-2-AMINO-6-{(E)-[(4-METHYLPHENYL)IMINO]METHYL}-4-OXO-4,6,7,8-TETRAHYDROPTERIDINE-5(4AH)-CARBALDEHYDE'>FNX</scene>, <scene name='pdbligand=G3N:(2R,3R,4S,5S)-5-AMINO-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL+[(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>G3N</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">arnA, ECHG_02161 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=656414 Escherichia coli H736])</td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FNX:(4AS,6S)-2-AMINO-6-{(E)-[(4-METHYLPHENYL)IMINO]METHYL}-4-OXO-4,6,7,8-TETRAHYDROPTERIDINE-5(4AH)-CARBALDEHYDE'>FNX</scene>, <scene name='pdbligand=G3N:(2R,3R,4S,5S)-5-AMINO-3,4-DIHYDROXYTETRAHYDRO-2H-PYRAN-2-YL+[(2R,3S,4R,5R)-5-(2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL+DIHYDROGEN+DIPHOSPHATE'>G3N</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j63 OCA], [http://pdbe.org/5j63 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j63 RCSB], [http://www.ebi.ac.uk/pdbsum/5j63 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j63 ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j63 OCA], [https://pdbe.org/5j63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j63 RCSB], [https://www.ebi.ac.uk/pdbsum/5j63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j63 ProSAT]</span></td></tr>
</table>
</table>
-
== Function ==
 
-
[[http://www.uniprot.org/uniprot/F4SGI5_ECOLX F4SGI5_ECOLX]] Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto-arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido-arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides.[HAMAP-Rule:MF_01166][SAAS:SAAS00331614]
 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 21:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: Escherichia coli h736]]
+
[[Category: Escherichia coli H736]]
-
[[Category: Genthe, N A]]
+
[[Category: Large Structures]]
-
[[Category: Holden, H M]]
+
[[Category: Genthe NA]]
-
[[Category: Thoden, J B]]
+
[[Category: Holden HM]]
-
[[Category: Lipopolysaccharide]]
+
[[Category: Thoden JB]]
-
[[Category: Transferase]]
+

Current revision

Crystal Structure of the N-terminal N-formyltransferase Domain (residues 1-306) of Escherichia coli Arna in Complex with UDP-Ara4N and Folinic Acid

PDB ID 5j63

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/5j63"
Personal tools