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| | ==Faustovirus major capsid protein== | | ==Faustovirus major capsid protein== |
| - | <StructureSection load='5j7o' size='340' side='right' caption='[[5j7o]], [[Resolution|resolution]] 2.37Å' scene=''> | + | <StructureSection load='5j7o' size='340' side='right'caption='[[5j7o]], [[Resolution|resolution]] 2.37Å' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[5j7o]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Faustovirus Faustovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J7O FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[5j7o]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Faustovirus Faustovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J7O FirstGlance]. <br> |
| - | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.37Å</td></tr> |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5j7v|5j7v]], [[5j7u|5j7u]]</td></tr>
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7o OCA], [https://pdbe.org/5j7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j7o RCSB], [https://www.ebi.ac.uk/pdbsum/5j7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j7o ProSAT]</span></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j7o OCA], [http://pdbe.org/5j7o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j7o RCSB], [http://www.ebi.ac.uk/pdbsum/5j7o PDBsum]</span></td></tr> | + | |
| | </table> | | </table> |
| | + | == Function == |
| | + | [https://www.uniprot.org/uniprot/A0A0H3TLP8_9VIRU A0A0H3TLP8_9VIRU] |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | </StructureSection> | | </StructureSection> |
| | [[Category: Faustovirus]] | | [[Category: Faustovirus]] |
| - | [[Category: Klose, T]] | + | [[Category: Large Structures]] |
| - | [[Category: Rossmann, M G]] | + | [[Category: Klose T]] |
| - | [[Category: Capsid]] | + | [[Category: Rossmann MG]] |
| - | [[Category: Double jelly-roll]]
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| - | [[Category: Viral protein]]
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| - | [[Category: Virus]]
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| Structural highlights
Function
A0A0H3TLP8_9VIRU
Publication Abstract from PubMed
Many viruses protect their genome with a combination of a protein shell with or without a membrane layer. Here we describe the structure of faustovirus, the first DNA virus (to our knowledge) that has been found to use two protein shells to encapsidate and protect its genome. The crystal structure of the major capsid protein, in combination with cryo-electron microscopy structures of two different maturation stages of the virus, shows that the outer virus shell is composed of a double jelly-roll protein that can be found in many double-stranded DNA viruses. The structure of the repeating hexameric unit of the inner shell is different from all other known capsid proteins. In addition to the unique architecture, the region of the genome that encodes the major capsid protein stretches over 17,000 bp and contains a large number of introns and exons. This complexity might help the virus to rapidly adapt to new environments or hosts.
Structure of faustovirus, a large dsDNA virus.,Klose T, Reteno DG, Benamar S, Hollerbach A, Colson P, La Scola B, Rossmann MG Proc Natl Acad Sci U S A. 2016 May 16. pii: 201523999. PMID:27185929[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Klose T, Reteno DG, Benamar S, Hollerbach A, Colson P, La Scola B, Rossmann MG. Structure of faustovirus, a large dsDNA virus. Proc Natl Acad Sci U S A. 2016 May 16. pii: 201523999. PMID:27185929 doi:http://dx.doi.org/10.1073/pnas.1523999113
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