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5j8v

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==Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion==
==Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion==
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<StructureSection load='5j8v' size='340' side='right' caption='[[5j8v]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
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<SX load='5j8v' size='340' side='right' viewer='molstar' caption='[[5j8v]], [[Resolution|resolution]] 4.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5J8V FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5j8v]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5J8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5J8V FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5j8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8v OCA], [http://pdbe.org/5j8v PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5j8v RCSB], [http://www.ebi.ac.uk/pdbsum/5j8v PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8v ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.9&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5j8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5j8v OCA], [https://pdbe.org/5j8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5j8v RCSB], [https://www.ebi.ac.uk/pdbsum/5j8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5j8v ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT]] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
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[https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 5j8v" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 5j8v" style="background-color:#fffaf0;"></div>
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==See Also==
 
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*[[Ryanodine receptor|Ryanodine receptor]]
 
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
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</StructureSection>
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</SX>
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[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Oryctolagus cuniculus]]
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[[Category: Sun, F]]
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[[Category: Sun F]]
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[[Category: Wang, X]]
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[[Category: Wang X]]
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[[Category: Wei, R]]
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[[Category: Wei R]]
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[[Category: Yin, C]]
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[[Category: Yin C]]
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[[Category: Activated by calcium ion]]
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[[Category: Endoplasmic reticula]]
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[[Category: Intracellular calcium ion channel]]
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[[Category: Skeletal muscle]]
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[[Category: Transport protein]]
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Current revision

Structure of rabbit ryanodine receptor RyR1 open state activated by calcium ion

5j8v, resolution 4.90Å

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