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Potassium channel 3D structures

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(New page: == 3D structures of Potassium Channels== Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} {{#tree:id=OrganizedByTopic|openlevels=0| *Potassium Channel **[[2p...)
Current revision (09:20, 7 September 2023) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 19: Line 19:
**[[4llo]] – mKCh EAG1 <br />
**[[4llo]] – mKCh EAG1 <br />
**[[5u76]], [[5u70]], [[5a6g]], [[5a6f]], [[5a6e]] – cKCh SLO2.2 – chicken – CryoEM<br />
**[[5u76]], [[5u70]], [[5a6g]], [[5a6f]], [[5a6e]] – cKCh SLO2.2 – chicken – CryoEM<br />
 +
**[[7atz]], [[7fcv]], [[7t4x]], [[7wsw]] – AtKCh AKT1 – ''Arabidopsis thaliana'' – Cryo EM<br />
 +
**[[1ho2]], [[1ho7]] - DmKCh L45 segment - ''Drosophila melanogaster'' - NMR<br />
 +
**[[5aar]] – AtKCh AKT1 ankyrin domain – ''Arabidopsis thaliana''<br />
 +
**[[8jet]], [[8jeu]] – AtKCh SKOR – Cryo EM<br />
 +
**[[8jec]] – AtKCh SKOR (mutant) – Cryo EM<br />
**[[1wlj]], [[2wlh]], [[2wli]], [[2wlj]], [[2wlm]], [[2wln]], [[2wlo]] - MmKCh - ''Magnetospirillum magnetoacticum''<br />
**[[1wlj]], [[2wlh]], [[2wli]], [[2wlj]], [[2wlm]], [[2wln]], [[2wlo]] - MmKCh - ''Magnetospirillum magnetoacticum''<br />
**[[2k44]] – KCh voltage-sensor paddle domain – NMR<br />
**[[2k44]] – KCh voltage-sensor paddle domain – NMR<br />
-
**[[3e86]], [[3e83]] – BcKCh transmembrane domain – ''Bacillus cereus''<br />
+
**[[3e86]], [[3e83]], [[6ufe]] – BcKCh transmembrane domain – ''Bacillus cereus''<br />
-
**[[3e8g]], [[3e89]], [[3e8b]], [[3e8f]], [[3e8h]], [[6dz1]], [[6cpv]] – BcKCh transmembrane domain +ions<br />
+
**[[3e8g]], [[3e89]], [[3e8b]], [[3e8f]], [[3e8h]], [[6dz1]], [[6cpv]] – BcKCh transmembrane domain 86-119 +ions<br />
-
**[[4r8c]], [[4r50]], [[2ahz]], [[2ahy]], [[4rai]], [[2q67]], [[2q68]], [[2q69]], [[2q6a]], [[3ouf]], [[4pdv]], [[4pdr]], [[4pdl]], [[4pdm]], [[4ro2]], [[4r7c]], [[4r6z]] – BcKCh transmembrane domain (mutant) + ion<br />
+
**[[4r8c]], [[4r50]], [[2ahz]], [[2ahy]], [[4rai]], [[2q67]], [[2q68]], [[2q69]], [[2q6a]], [[3ouf]], [[4pdv]], [[4pdr]], [[4pdl]], [[4pdm]], [[4ro2]], [[4r7c]], [[4r6z]], [[7oor]], [[7oou]], [[7oph]], [[7oq1]], [[7oq2]], [[7pa0]], [[8a35]], [[8a7x]], [[8ayp]], [[8ayq]], [[8cts]], [[8ctt]], [[8ctu]], [[8ctv]], [[8ctw]], [[8ctx]] – BcKCh transmembrane domain (mutant) + ion<br />
 +
**[[8ctn]], [[8cu1]], [[8cu2]], [[8cu3]], [[8cu4]] – BcKCh transmembrane domain (mutant) + ion - Laue<br />
**[[4pdv]], [[4pdr]], [[4pdl]], [[4pdm]] – BcKCh (mutant)<br />
**[[4pdv]], [[4pdr]], [[4pdl]], [[4pdm]] – BcKCh (mutant)<br />
-
**[[1bl8]], [[1f6g]] - SlKCh Kcsa (mutant) - ''Streptomyces lividans''<br />
+
**[[1bl8]], [[1f6g]], [[7mhx]], [[7mjt]], [[7mk6]] - SlKCh Kcsa (mutant) - ''Streptomyces lividans''<br />
-
**[[2qto]] - SlKCh Kcsa<br />
+
**[[2qto]], [[3ifx]] - SlKCh Kcsa pore domain 1-120<br />
-
**[[1j95]] - SlKCh Kcsa +K+tetrabutylammonium<br />
+
**[[1j95]] - SlKCh Kcsa pore domain +K+tetrabutylammonium<br />
-
**[[1jvm]] - SlKCh Kcsa (mutant)+Rb+tetrabutylammonium<br />
+
**[[1jvm]] - SlKCh Kcsa pore domain (mutant)+Rb+tetrabutylammonium<br />
**[[1jq1]], [[1jq2]] - SlKCh Kcsa inner transmembrane segment - NMR<br />
**[[1jq1]], [[1jq2]] - SlKCh Kcsa inner transmembrane segment - NMR<br />
-
**[[3ifx]] - SlKCh Kcsa pore domain<br />
 
**[[1a68]], [[1eod]], [[1eoe]], [[1eof]], [[3kvt]] - AcKCh Kv1.1 T1 domain (mutant) - ''Aplysia californica''<br />
**[[1a68]], [[1eod]], [[1eoe]], [[1eof]], [[3kvt]] - AcKCh Kv1.1 T1 domain (mutant) - ''Aplysia californica''<br />
**[[1t1d]] - AcKCh Kv1.1 T1 domain<br />
**[[1t1d]] - AcKCh Kv1.1 T1 domain<br />
**[[6eo1]] - MlotiK1 + K – ''Mesorhizobium loti''<br />
**[[6eo1]] - MlotiK1 + K – ''Mesorhizobium loti''<br />
**[[3co2]], [[1vp6]] - MlotiK1 cyclic nucleotide binding domain - ''Mesorhizobium loti''<br />
**[[3co2]], [[1vp6]] - MlotiK1 cyclic nucleotide binding domain - ''Mesorhizobium loti''<br />
-
**[[1ho2]], [[1ho7]] - DmKCh L45 segment - ''Drosophila melanogaster'' - NMR<br />
 
**[[2kyh]] - AeKCh voltage ensing domain - ''Aeropyrum pernix'' - NMR<br />
**[[2kyh]] - AeKCh voltage ensing domain - ''Aeropyrum pernix'' - NMR<br />
-
**[[2wll]] - KCh KIRBAC1.1 - ''Burkholderia pseudomalie''<br />
+
**[[6uwm]] – AeKCH residues 25-295 – Cryo EM<br />
 +
**[[2wll]] - BpKCh KIRBAC1.1 - ''Burkholderia pseudomalie''<br />
 +
**[[7swj]] – BpKCh KIRBAC1.1 (mutant) – NMR<br />
**[[1bei]] - KCh Kv1.3 – ''Stichodactyla helianthus''<br />
**[[1bei]] - KCh Kv1.3 – ''Stichodactyla helianthus''<br />
Line 48: Line 54:
**[[2r9r]] - rKCh Kv2.1/KCh Kv1.2 + Kv β-2<br />
**[[2r9r]] - rKCh Kv2.1/KCh Kv1.2 + Kv β-2<br />
**[[1exb]] - rKCh Kv1.1 T1 domain + KV beta2 protein<br />
**[[1exb]] - rKCh Kv1.1 T1 domain + KV beta2 protein<br />
 +
**[[8ep0]], [[8ep1]] - rKCh Kv10.1 + calmodulin – Cryo EM <br />
**[[2p7t]] - rKCh + FAV<br />
**[[2p7t]] - rKCh + FAV<br />
-
**[[3lnm]], [[6ebl]], [[6ebk]] - rKCh Kv2.1/KCh Kv1.2 (mutant)<br />
+
**[[3lnm]], [[6ebl]], [[6ebk]], [[6ebm]] - rKCh Kv2.1/KCh Kv1.2 (mutant)<br />
 +
**[[7siz]] - rKCh Kv2.1/KCh Kv1.2 (mutant) + beta2 subunit<br />
**[[5k7l]] - rKCh EAG1 + calmodulin <br />
**[[5k7l]] - rKCh EAG1 + calmodulin <br />
-
**[[6pbx]], [[6pby]] - rKCh EAG1 + calmodulin – Cryo EM <br />
+
**[[6pbx]], [[6pby]], [[8eow]] - rKCh EAG1 + calmodulin – Cryo EM <br />
**[[3eff]] - mKCh + FAB <br />
**[[3eff]] - mKCh + FAB <br />
**[[2w0f]] - mKCh + FAB + tetraoctylammonium<br />
**[[2w0f]] - mKCh + FAB + tetraoctylammonium<br />
 +
**[[6wlv]], [[6wm0]] - mKCh TASK-2 – Cryo EM <br />
**[[2hg5]], [[2h8p]], [[2hfe]] - KCh + mFAB<br />
**[[2hg5]], [[2h8p]], [[2hfe]] - KCh + mFAB<br />
**[[3f7v]], [[3f7y]], [[3fb5]], [[3fb7]], [[3fb8]], [[3gb7]], [[3hpl]], [[3iga]], [[3or6]], [[3or7]], [[1r3i]], [[1r3j]], [[1r3k]],[[1r3l]], [[1s5h]], [[2atk]], [[2bob]], [[2boc]], [[2dwd]], [[2dwe]], [[2hvj]], [[2hvk]], [[2ih1]], [[2ih3]], [[2itc]], [[2itd]], [[2jk5]], [[2nlj]] - mKCh (mutant) + FAB<br />
**[[3f7v]], [[3f7y]], [[3fb5]], [[3fb7]], [[3fb8]], [[3gb7]], [[3hpl]], [[3iga]], [[3or6]], [[3or7]], [[1r3i]], [[1r3j]], [[1r3k]],[[1r3l]], [[1s5h]], [[2atk]], [[2bob]], [[2boc]], [[2dwd]], [[2dwe]], [[2hvj]], [[2hvk]], [[2ih1]], [[2ih3]], [[2itc]], [[2itd]], [[2jk5]], [[2nlj]] - mKCh (mutant) + FAB<br />
**[[3f5w]], [[1zwi]], [[2hjf]] - mKCh (mutant) + antibody heavy+light chains<br />
**[[3f5w]], [[1zwi]], [[2hjf]] - mKCh (mutant) + antibody heavy+light chains<br />
-
**[[5vms]] - KCh Kv7.1 + calmodulin - frog <br />
+
**[[5vms]] - fKCh Kv7.1 + calmodulin - frog <br />
-
**[[3pjs]], [[5j9p]], [[4uuj]], [[4msw]], [[5vkh]], [[5vke]], [[5vk6]] – SlKCh Kcsa + antibody<br />
+
**[[7tci]], [[7tcp]] - fKCh Kv7.1 + calmodulin – Cryo EM <br />
-
**[[1k4c]], [[1k4d]], [[4lcu]], [[5ec2]], [[5ec1]], [[5ebw]], [[5ebm]], [[5ebl]], [[5e1a]], [[4lbe]], [[6pa0]], [[6nfu]], [[6nfv]] - SlKCh Kcsa (mutant) + antibody <br />
+
**[[3pjs]], [[5j9p]], [[4uuj]], [[4msw]], [[5vkh]], [[5vke]], [[5vk6]], [[6w0a]], [[6w0b]], [[6w0c]], [[6w0d]], [[6w0e]], [[6w0f]], [[6w0g]], [[6w0h]], [[6w0i]], [[6w0j]], [[7m2h]], [[7m2i]], [[7m2j]], [[7mdj]], [[7rp0]] – SlKCh Kcsa pore domain + antibody<br />
-
**[[2a9h]] - SlKCh Kcsa (mutant) + charybdotoxin<br />
+
**[[1k4c]], [[1k4d]], [[4lcu]], [[5ec2]], [[5ec1]], [[5ebw]], [[5ebm]], [[5ebl]], [[5e1a]], [[4lbe]], [[6pa0]], [[6nfu]], [[6nfv]], [[7mub]], [[7sqw]] - SlKCh Kcsa pore domain (mutant) + antibody <br />
 +
**[[7mhr]] - SlKCh Kcsa pore domain (mutant) + antibody + K<br />
 +
**[[2a9h]] - SlKCh Kcsa pore domain (mutant) + charybdotoxin<br />
**[[6by2]], [[6by3]] - KCh Kcsa (mutant) + antibody – ''Streptomyces coelicolor''<br />
**[[6by2]], [[6by3]] - KCh Kcsa (mutant) + antibody – ''Streptomyces coelicolor''<br />
**[[2a0l]] - AeKCh + FV<br />
**[[2a0l]] - AeKCh + FV<br />
Line 68: Line 79:
*Human potassium Channel
*Human potassium Channel
-
**[[1b4g]], [[1b4i]] - hKCh inactivation domain - human - NMR<br />
+
**[[4hqa]], [[4hp9]] - hKCh ERG PAS domain 1-135 - human<br />
-
**[[1byw]] - hKCh ERG N-terminal (mutant)<br />
+
**[[1byw]] – hKCh ERG PAS domain (mutant)<br />
-
**[[4hqa]], [[4hp9]] - hKCh ERG PAS domain<br />
+
**[[2l1m]], [[2l4r]] – hKCh PAS domain – NMR<br />
-
**[[1ujl]] - hKCh ERG1 extracellular linker - NMR<br />
+
**[[1b4g]], [[1b4l]], [[1ujl]] - hKCh ERG1 extracellular linker 1-42 – NMR<br />
-
**[[2l1m]], [[2l4r]], [[2l0w]] - hKCh HERG - NMR<br />
+
**[[7ej1]], [[7ssx]], [[7ssy]], [[7wf3]] – hKCh Kv1.3 - CryoEM<br />
-
**[[1s1g]] - hKCh Kv4.3 T1 domain<br />
+
**[[7ej2]] – hKCh Kv1.3 (mutant) - CryoEM<br />
-
**[[2nz0]] – hKCh Kv4.3 N-terminal+KV channel interacting protein 1 <br />
+
**[[7re5]], [[7spd]] – hKCh Kv2.1 tetramerization domain <br />
-
**[[2ovc]] - hKCh Kv7.4 T1 domain<br />
+
**[[7phh]], [[7phi]], [[7phk]], [[7phl]], [[7pqt]] – hKCh Kv3.1 - CryoEM<br />
-
**[[3bj4]] - hKCh Kv7.1 C-termianl<br />
+
**[[7f0j]] – hKCh Kv4.2 - CryoEM<br />
-
**[[3hfc]], [[3hfe]] - hKCh Kv7.1 (mutant) <br />
+
**[[7w3y]] – hKCh Kv4.3 - CryoEM<br />
 +
**[[1s1g]] - hKCh Kv4.3 T1 domain)<br />
 +
**[[2ovc]] - hKCh Kv7.4 T1 domain)<br />
 +
**[[3bj4]] - hKCh Kv7.1 C-terminal)<br />
 +
**[[7vvh]] - hKCh Kv7.1 C-terminal (mutant <br />
 +
**[[3hfc]], [[3hfe]] – hKCh Kv7.1 (mutant)<br />
 +
**[[7cr0]] – hKCh Kv7.2 - CryoEM<br />
 +
**[[6syg]] – hKCh Kv11.1 NBD<br />
**[[5va2]], [[5va1]] – hKCh Kv11.1 - CryoEM<br />
**[[5va2]], [[5va1]] – hKCh Kv11.1 - CryoEM<br />
**[[5va3]] – hKCh Kv11.1 (mutant) - CryoEM<br />
**[[5va3]] – hKCh Kv11.1 (mutant) - CryoEM<br />
-
**[[1zsx]] - hKCh β-2<br />
+
**[[1zsx]] – hKCh β-2 subunit)<br />
**[[5j7e]] – hKCh EAG1 PAS domain<br />
**[[5j7e]] – hKCh EAG1 PAS domain<br />
-
**[[1ztn]] – hKCH RAW3 inactivation gate – NMR<br />
+
**[[1ztn]] – hKCH RAW3 inactivation gate – NMR)<br />
-
**[[1zto]] - hKCH RCK4 inactivation gate – NMR<br />
+
**[[1zto]] - hKCH RCK4 inactivation gate – NMR)<br />
 +
**[[6rv2]] - hKCh TASK-1 <br />
 +
**[[7yid]], [[7yie]], [[7yif]], [[7yig]], [[7yih]], [[7yij]] – hKCh KCNH5 - CryoEM<br />
 +
 
 +
*Human potassium channel complex
 +
 
 +
**[[7cn0]], [[7cn1]] – hKCh ERG + K - CryoEM<br />
 +
**[[7ssz]], [[8dfl]] – hKCh Kv1.3 + nanobody - CryoEM<br />
 +
**[[7pqu]] – hKCh Kv3.1 + K - CryoEM<br />
 +
**[[7wf4]] – hKCh Kv3.1 + Kv beta-2 + NADP - CryoEM<br />
 +
**[[6pis]], [[7lj4]], [[7lj5]], [[7lja]], [[7ljb]] – hKCh Kv4.1 (mutant) + antibody<br />
 +
**[[7e7z]], [[7e83]], [[7e84]], [[7f3f]] – hKCh Kv4.2 + KChlP1 - CryoEM<br />
 +
**[[7e87]], [[7e8b]] – hKCh Kv4.2 + DPP6S - CryoEM<br />
 +
**[[7e86]], [[7e8e]], [[7e8h]] – hKCh Kv4.2 + KChlP1 + DPP6S - CryoEM<br />
 +
**[[7ukd]], [[7ukf]] – hKCh Kv4.2 + KChlP2 - CryoEM<br />
 +
**[[7ukg]], [[7ukh]] – hKCh Kv4.2 + KChlP2 + DPP6 - CryoEM<br />
 +
**[[7uk5]], [[7ukc]], [[7uke]] – hKCh Kv4.2 transmembrane region + KChlP2 - CryoEM<br />
 +
**[[7w6n]] – hKCh Kv4.3 + KChlP1 - CryoEM<br />
 +
**[[7w6t]] – hKCh Kv4.3 + KChlP1 + DPP6 - CryoEM<br />
 +
**[[7w6s]] – hKCh Kv4.3 + KChlP2 - CryoEM<br />
 +
**[[2nz0]] – hKCh Kv4.3 N-terminal+KV channel interacting protein 1)<br />
**[[4v0c]] - hKCh Kv7.1 + calmodulin <br />
**[[4v0c]] - hKCh Kv7.1 + calmodulin <br />
**[[4umo]] - hKCh Kv7.1 (mutant) + calmodulin <br />
**[[4umo]] - hKCh Kv7.1 (mutant) + calmodulin <br />
**[[5j03]], [[6feh]], [[6feg]] - hKCh Kv7.2 + calmodulin <br />
**[[5j03]], [[6feh]], [[6feg]] - hKCh Kv7.2 + calmodulin <br />
-
**[[6b8p]], [[6b8n]], [[6b8m]], [[6b8l]], [[6n5w]] - hKCh Kv7.4 + calmodulin <br />
 
**[[6b8q]] - hKCh Kv7.5 + calmodulin <br />
**[[6b8q]] - hKCh Kv7.5 + calmodulin <br />
-
**[[6rv2]] - hKCh TASK-1 <br />
 
**[[6rv3]], [[6rv4]] - hKCh TASK-1 + inhibitor <br />
**[[6rv3]], [[6rv4]] - hKCh TASK-1 + inhibitor <br />
 +
**[[7xni]], [[7xnk]], [[7xnl]], [[7xnn]], [[8sik]], [[8sim]] – hKCh KCNQ1 + calmodulin + K - CryoEM<br />
 +
**[[6uzz]], [[6v00]] – hKCh KCNQ1 + KCNE3 + calmodulin - CryoEM<br />
 +
**[[6v01]] – hKCh KCNQ1 + KCNE3 + calmodulin + PTDINS - CryoEM<br />
 +
**[[7cr3]] – hKCh KCNQ2 + calmodulin - CryoEM<br />
 +
**[[7cr1]] – hKCh KCNQ2 + pyridine derivative - CryoEM<br />
 +
**[[7cr4]] – hKCh KCNQ2 + pyridine derivative + calmodulin - CryoEM<br />
 +
**[[7cr2]] – hKCh KCNQ2 + drug - CryoEM<br />
 +
**[[7cr7]] – hKCh KCNQ2 + calmodulin + drug - CryoEM<br />
 +
**[[6b8p]], [[6b8n]], [[6b8m]], [[6b8l]], [[6n5w]], [[7byl]], [[7vnp]], [[7vnq]], [[7vnr]] – hKCh KCNQ4 + calmodulin - CryoEM<br />
 +
**[[7bym]], [[7byn]] – hKCh KCNQ4 + calmodulin + drug - CryoEM<br />
*Inward rectifier KCh
*Inward rectifier KCh
-
**[[6c3p]], [[6c3o]] - hIRK 11 + SUR1 + ATP + ADP – Cryo EM<br />
+
**[[7s5t]] - hIRK 11 – Cryo EM<br />
 +
**[[6c3p]], [[6c3o]], [[7s5v]] - hIRK 11 + SUR1 + ATP + ADP – Cryo EM<br />
 +
**[[7s5x]], [[7s5y]], [[7s5z]], [[7s60]], [[7s61]] - hIRK 11 (mutant) + sulfonylurea receptor + ATP + ADP – Cryo EM<br />
**[[6baa]] - hIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
**[[6baa]] - hIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
**[[3ukm]] – hIRK TWIK-1<br />
**[[3ukm]] – hIRK TWIK-1<br />
Line 101: Line 149:
**[[4wfh]], [[4wfg]], [[4wfe]], [[4wff]] - hIRK TRAAK + antibody<br />
**[[4wfh]], [[4wfg]], [[4wfe]], [[4wff]] - hIRK TRAAK + antibody<br />
**[[4i9w]] - hIRK TRAAK (mutant) + antibody<br />
**[[4i9w]] - hIRK TRAAK (mutant) + antibody<br />
 +
**[[7zdz]] – hKir2.1 + K – Cryo EM<br />
 +
**[[7wit]] - bIRK 11 + SUR1 + ATP + diabetes drug – bovine - Cryo EM<br /
**[[6pz9]], [[6pza]], [[5twv]] - rIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
**[[6pz9]], [[6pza]], [[5twv]] - rIRK 11 + SUR1 + ATP + diabetes drug – Cryo EM<br />
 +
**[[7sk0]], [[7sk1]] - rTWIK1 – Cryo EM<br />
 +
**[[7mit]], [[7mjo]], [[7mjp]], [[7mjq]] – rKATP Kir6.1 + ATP – Cryo EM<br />
 +
**[[7u24]], [[7uqr]] – rKATP Kir6.2 + SUR1 – Cryo EM<br />
 +
**[[7u1e]] – rKATP Kir6.2 + SUR1 + ATP – Cryo EM<br />
 +
**[[7tyt]], [[7u1q]], [[7u1s]], [[7u2x]], [[7u6y]], [[7u7m]], [[7uaa]] – rKATP Kir6.2 + SUR1 + ATP + drug – Cryo EM<br />
 +
**[[7w4o]], [[7w4p]] – mKATP Kir6.2 (mutant) + SUR1 – Cryo EM<br />
**[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br />
**[[1u4f]],[[3agw]] - mIRK 2 cytoplasmic domain<br />
**[[2xky]] - mIRK 2 cytoplasmic domain - EM<br />
**[[2xky]] - mIRK 2 cytoplasmic domain - EM<br />
Line 110: Line 166:
**[[5um4]] - mIRK 3.1 (mutant)<br />
**[[5um4]] - mIRK 3.1 (mutant)<br />
**[[3at8]], [[3at9]], [[3ata]], [[3atb]], [[3atd]], [[3ate]], [[3atf]], [[3auw]], [[3syo]] - mIRK 3.2<br />
**[[3at8]], [[3at9]], [[3ata]], [[3atb]], [[3atd]], [[3ate]], [[3atf]], [[3auw]], [[3syo]] - mIRK 3.2<br />
 +
**[[6xis]], [[6xit]] - mIRK 3.2 – Cryo EM<br />
**[[3syc]], [[3syp]] - mIRK 3.2 (mutant) <br />
**[[3syc]], [[3syp]] - mIRK 3.2 (mutant) <br />
**[[3sya]] - mIRK 3.2 + PIP2<br />
**[[3sya]] - mIRK 3.2 + PIP2<br />
 +
**[[6xeu]] - mGIRK 2 + PIP2 – Cryo EM<br />
 +
**[[6xev]] - mGIRK 2 + PIP2 + cholesterol derivative – Cryo EM<br />
**[[3syq]] - mIRK 3.2 (mutant) + PIP2<br />
**[[3syq]] - mIRK 3.2 (mutant) + PIP2<br />
**[[4kfm]] - mIRK 3.2 + guanine nucleotide-biding protein<br />
**[[4kfm]] - mIRK 3.2 + guanine nucleotide-biding protein<br />
Line 123: Line 182:
**[[3spg]], [[3sph]], [[5kum]], [[5kuk]], [[6m84]] – cIRK 2.2 (mutant) + PIP2<br />
**[[3spg]], [[3sph]], [[5kum]], [[5kuk]], [[6m84]] – cIRK 2.2 (mutant) + PIP2<br />
**[[3spi]] – cIRK 2.2 + PIP2<br />
**[[3spi]] – cIRK 2.2 + PIP2<br />
-
**[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]] - MmIRK KIRBAC3.1<br />
+
**[[6v1x]], [[6v1y]], [[7cal]], [[7wm2]] - AtIRK KAT1 – Cryo EM<br />
-
**[[4lp8]] - MmIRK KIRBAC3.1 (mutant) <br />
+
**[[7wm1]], [[7xuf]] - AtIRK KAT3 + AKT1 – Cryo EM<br />
 +
**[[1xl4]], [[1xl6]], [[2wlk]], [[2x6a]], [[2x6b]], [[2x6c]], [[6o9u]] - MmIRK KIRBac3.1<br />
 +
**[[4lp8]], [[6o9t]], [[6o9v]], [[7adi]], [[7n9k]], [[7n9l]] - MmIRK KIRBac3.1 (mutant) <br />
**[[3zrs]] – MmIRK 10<br />
**[[3zrs]] – MmIRK 10<br />
**[[1p7b]] - BpIRK C-terminal<br />
**[[1p7b]] - BpIRK C-terminal<br />
Line 133: Line 194:
**[[4bw5]], [[4xdj]] – hKCh TREK-2<br />
**[[4bw5]], [[4xdj]] – hKCh TREK-2<br />
**[[4xdl]], [[4xdk]] – hKCh TREK-2 + Prozac derivative<br />
**[[4xdl]], [[4xdk]] – hKCh TREK-2 + Prozac derivative<br />
-
**[[6cq9]], [[6cq8]], [[6cq6]] – mKCh TREK-1 (mutant)<br />
+
**[[6cq6]], [[6cq8]], [[6cq9]], [[6v36]], [[6v37]], [[6v3c]], [[6v3i]], [[6w7b]], [[6w7c]], [[6w7d]], [[6w7e]], [[6w82]], [[6w83]], [[6w84]], [[6w85]], [[6w86]], [[6w87]], [[6w88]], [[6w8a]], [[6w8c]], [[6w8f]] – mKCh TREK-1 (mutant)<br />
 +
**[[8de7]], [[8de8]], [[8de9]] – KCh TREK-1 – zebrafish – Cryo EM<br />
*MthK
*MthK
-
**[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]], [[4ro0]] - MthK RCK domain - ''Methanobacterium thermoautrophicum''<br />
+
**[[6u5n]], [[6u5p]], [[6u5r]], [[6u68]], [[6u6d]], [[6u6e]], [[6u6h]], [[6u9p]], [[6u9t]], [[6u9y]], [[6u9z]] - MthK - ''Methanobacterium thermoautrophicum'' – Cryo EM<br />
 +
**[[6oly]] - MthK (mutant) <br />
 +
**[[8djb]] - MthK (mutant) – Cryo EM<br />
 +
**[[2ogu]], [[2fy8]], [[2aej]], [[2aem]], [[1lnq]], [[4ro0]] - MthK RCK domain <br />
**[[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br />
**[[3ldc]], [[3ldd]], [[3lde]], [[3ous]] – MthK residues 28-99 (mutant)<br />
**[[4qe9]], [[4qe7]] - MthK residues 18-100 (mutant)<br />
**[[4qe9]], [[4qe7]] - MthK residues 18-100 (mutant)<br />
**[[2aef]], [[3kxd]], [[4ei2]], [[4l73]], [[4l74]], [[4l75]], [[4l76]] - MthK RCK domain + Ca<br />
**[[2aef]], [[3kxd]], [[4ei2]], [[4l73]], [[4l74]], [[4l75]], [[4l76]] - MthK RCK domain + Ca<br />
 +
**[[6uwn]], [[6ux4]], [[6ux7]], [[6uxa]], [[6uxb]] - MthK RCK domain + Ca – Cryo EM<br />
**[[3rbx]], [[3rbz]] - MthK RCK domain (mutant) + Ca<br />
**[[3rbx]], [[3rbz]] - MthK RCK domain (mutant) + Ca<br />
**[[3r65]], [[4hyo]], [[4hz3]] – MthK pore domain (mutant)
**[[3r65]], [[4hyo]], [[4hz3]] – MthK pore domain (mutant)
- 
-
*Large conductance calcium-activated KCh
 
- 
-
**[[3mt5]] - hBK cytoplasmic domain<br />
 
-
**[[1jo6]] - BK beta 2 N-terminal KCNMB2 encoded LKCa - NMR<br />
 
-
**[[3u6n]] – BK – ''Danio rerio''<br />
 
-
**[[5tji]], [[5tj6]] – AcBK - CryoEM<br />
 
*Potassium/Sodium channel
*Potassium/Sodium channel
Line 158: Line 217:
*Calcium-activated KCh
*Calcium-activated KCh
-
**[[3naf]] – hKCh α1 subunit<br />
+
**[[3naf]], [[6nd0]] – hKCh α1 subunit<br />
 +
**[[6v3g]], [[8ghf]] – hKCh 1 subunit – Cryo EM<br />
 +
**[[6v38]] – hKCh 1 subunit + Ca – Cryo EM<br />
 +
**[[6v5a]] – hKCh 1 subunit (mutant) + Ca <br />
 +
**[[8gh9]], [[8ghg]] – hKCh SLO1 – CryoEM<br />
 +
**[[8hir]], [[8hk6]], [[8hkf]], [[8hkk]], [[8hkm]], [[8hkq]] – hKCh SLO2.2 – CryoEM<br />
 +
**[[7yo3]] – hKCh SLO1 subunit alpha1+ LRRC26 – CryoEM<br />
 +
**[[6v22]], [[6v35]] – hKCh α1+β4 subunits + Ca – Cryo EM<br />
**[[4hpf]] - hKCh α 3 subunit<br />
**[[4hpf]] - hKCh α 3 subunit<br />
**[[5y7l]] - hKCh β 4 subunit extracellular loop<br />
**[[5y7l]] - hKCh β 4 subunit extracellular loop<br />
 +
**[[7pxe]], [[7pxf]] – DmKCH – Cryo EM<br />
 +
**[[7pxg]], [[7pxh]] – DmKCh + modulator – Cryo EM<br />
*Small conductance calcium-activated KCh; Domains - calmodulin-binding 395-487; leucine zipper 488-526
*Small conductance calcium-activated KCh; Domains - calmodulin-binding 395-487; leucine zipper 488-526
Line 174: Line 242:
**[[6cno]], [[6cnn]], [[6cnm]] - hKCa 3.1 + calmodulin – Cryo EM<br />
**[[6cno]], [[6cnn]], [[6cnm]] - hKCa 3.1 + calmodulin – Cryo EM<br />
**[[6d42]]- rKCa 3.1 C terminal<br />
**[[6d42]]- rKCa 3.1 C terminal<br />
 +
 +
*Large conductance calcium-activated KCh
 +
 +
**[[3mt5]] - hBK cytoplasmic domain<br />
 +
**[[1jo6]] - BK beta 2 N-terminal KCNMB2 encoded LKCa - synthetic - NMR<br />
 +
**[[3u6n]] – zBK<br />
 +
**[[5tji]], [[5tj6]] – AcBK - CryoEM<br />
*Potassium/Sodium hyperpolarization-activated cyclic nucleotide-gated channel or cyclic nucleotide-gated channel or HCN channel see [[Ion channels]]
*Potassium/Sodium hyperpolarization-activated cyclic nucleotide-gated channel or cyclic nucleotide-gated channel or HCN channel see [[Ion channels]]

Current revision

3D structures of Potassium Channels

Updated on 07-September-2023

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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