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8j69
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of HORMA domain-containing protein 1 (HORMAD1) from Homo sapiens== | |
| - | + | <StructureSection load='8j69' size='340' side='right'caption='[[8j69]], [[Resolution|resolution]] 2.67Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8j69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8J69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8J69 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.67Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8j69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8j69 OCA], [https://pdbe.org/8j69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8j69 RCSB], [https://www.ebi.ac.uk/pdbsum/8j69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8j69 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HORM1_HUMAN HORM1_HUMAN] Plays a key role in meiotic progression. Regulates 3 different functions during meiosis: ensures that sufficient numbers of processed DNA double-strand breaks (DSBs) are available for successful homology search by increasing the steady-state numbers of single-stranded DSB ends. Promotes synaptonemal-complex formation independently of its role in homology search. Plays a key role in the male mid-pachytene checkpoint and the female meiotic prophase checkpoint: required for efficient build-up of ATR activity on unsynapsed chromosome regions, a process believed to form the basis of meiotic silencing of unsynapsed chromatin (MSUC) and meiotic prophase quality control in both sexes.[UniProtKB:Q9D5T7] | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Liu XH]] | ||
| + | [[Category: Yang XY]] | ||
Current revision
Crystal structure of HORMA domain-containing protein 1 (HORMAD1) from Homo sapiens
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