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1vlh

From Proteopedia

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(New page: 200px<br /><applet load="1vlh" size="450" color="white" frame="true" align="right" spinBox="true" caption="1vlh, resolution 2.20&Aring;" /> '''Crystal structure of...)
Current revision (14:53, 20 September 2023) (edit) (undo)
 
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[[Image:1vlh.gif|left|200px]]<br /><applet load="1vlh" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="1vlh, resolution 2.20&Aring;" />
 
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'''Crystal structure of Phosphopantetheine adenylyltransferase (TM0741) from Thermotoga maritima at 2.20 A resolution'''<br />
 
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==About this Structure==
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==Crystal structure of Phosphopantetheine adenylyltransferase (TM0741) from Thermotoga maritima at 2.20 A resolution==
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1VLH is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima] with PNS and MPD as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pantetheine-phosphate_adenylyltransferase Pantetheine-phosphate adenylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.3 2.7.7.3] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1VLH OCA].
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<StructureSection load='1vlh' size='340' side='right'caption='[[1vlh]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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[[Category: Pantetheine-phosphate adenylyltransferase]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[1vlh]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VLH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VLH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene>, <scene name='pdbligand=PNS:4-PHOSPHOPANTETHEINE'>PNS</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vlh OCA], [https://pdbe.org/1vlh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vlh RCSB], [https://www.ebi.ac.uk/pdbsum/1vlh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vlh ProSAT], [https://www.topsan.org/Proteins/JCSG/1vlh TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COAD_THEMA COAD_THEMA] Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vl/1vlh_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vlh ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Thermotoga maritima]]
[[Category: Thermotoga maritima]]
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[[Category: JCSG, Joint.Center.for.Structural.Genomics.]]
 
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[[Category: MPD]]
 
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[[Category: PNS]]
 
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[[Category: jcsg]]
 
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[[Category: joint center for structural genomics]]
 
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[[Category: phosphopantetheine adenylyltransferase]]
 
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[[Category: protein structure initiative]]
 
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[[Category: psi]]
 
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[[Category: structural genomics]]
 
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[[Category: tm0741]]
 
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 04:56:13 2007''
 

Current revision

Crystal structure of Phosphopantetheine adenylyltransferase (TM0741) from Thermotoga maritima at 2.20 A resolution

PDB ID 1vlh

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