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1vp2
From Proteopedia
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| - | [[Image:1vp2.gif|left|200px]]<br /><applet load="1vp2" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="1vp2, resolution 1.78Å" /> | ||
| - | '''Crystal structure of Putative Xanthosine triphosphate pyrophosphatase/HAM1 protein homolog (TM0159) from Thermotoga maritima at 1.78 A resolution'''<br /> | ||
| - | == | + | ==CRYSTAL STRUCTURE OF A PUTATIVE XANTHOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN HOMOLOG (TM0159) FROM THERMOTOGA MARITIMA AT 1.78 A RESOLUTION== |
| - | + | <StructureSection load='1vp2' size='340' side='right'caption='[[1vp2]], [[Resolution|resolution]] 1.78Å' scene=''> | |
| - | [[ | + | == Structural highlights == |
| + | <table><tr><td colspan='2'>[[1vp2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VP2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VP2 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.78Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vp2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vp2 OCA], [https://pdbe.org/1vp2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vp2 RCSB], [https://www.ebi.ac.uk/pdbsum/1vp2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vp2 ProSAT], [https://www.topsan.org/Proteins/JCSG/1vp2 TOPSAN]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/IXTPA_THEMA IXTPA_THEMA] Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions.[HAMAP-Rule:MF_01405] | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vp/1vp2_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vp2 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Thermotoga maritima]] | [[Category: Thermotoga maritima]] | ||
| - | [[Category: JCSG, Joint Center for Structural Genomics.]] | ||
| - | [[Category: SO4]] | ||
| - | [[Category: jcsg]] | ||
| - | [[Category: joint center for structural genomics]] | ||
| - | [[Category: protein structure initiative]] | ||
| - | [[Category: psi]] | ||
| - | [[Category: putative xanthosine triphosphate pyrophosphatase (ec 3 6.1.-)/ham1 protein homolog]] | ||
| - | [[Category: structural genomics]] | ||
| - | [[Category: tm0159]] | ||
| - | |||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:37:06 2008'' | ||
Current revision
CRYSTAL STRUCTURE OF A PUTATIVE XANTHOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN HOMOLOG (TM0159) FROM THERMOTOGA MARITIMA AT 1.78 A RESOLUTION
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