1vq3

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[[Image:1vq3.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of Phosphoribosylformylglycinamidine synthase, purS subunit (EC 6.3.5.3) (TM1244) from Thermotoga maritima at 1.90 A resolution==
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|PDB= 1vq3 |SIZE=350|CAPTION= <scene name='initialview01'>1vq3</scene>, resolution 1.90&Aring;
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<StructureSection load='1vq3' size='340' side='right'caption='[[1vq3]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1vq3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1VQ3 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoribosylformylglycinamidine_synthase Phosphoribosylformylglycinamidine synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.3.5.3 6.3.5.3] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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|GENE= TM1244 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=243274 Thermotoga maritima MSB8])
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1vq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vq3 OCA], [https://pdbe.org/1vq3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1vq3 RCSB], [https://www.ebi.ac.uk/pdbsum/1vq3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1vq3 ProSAT], [https://www.topsan.org/Proteins/JCSG/1vq3 TOPSAN]</span></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=COG1828 PurS]</span>
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1vq3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1vq3 OCA], [http://www.ebi.ac.uk/pdbsum/1vq3 PDBsum], [http://www.fli-leibniz.de/cgi-bin/ImgLib.pl?CODE=1kfv JenaLib], [http://www.rcsb.org/pdb/explore.do?structureId=1vq3 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PURS_THEMA PURS_THEMA] Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL.[HAMAP-Rule:MF_01926]<ref>PMID:18597481</ref>
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== Evolutionary Conservation ==
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'''Crystal structure of Phosphoribosylformylglycinamidine synthase, purS subunit (EC 6.3.5.3) (TM1244) from Thermotoga maritima at 1.90 A resolution'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vq/1vq3_consurf.spt"</scriptWhenChecked>
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1VQ3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima_msb8 Thermotoga maritima msb8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1VQ3 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Phosphoribosylformylglycinamidine synthase]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Single protein]]
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</jmolCheckbox>
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[[Category: Thermotoga maritima msb8]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1vq3 ConSurf].
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[[Category: JCSG, Joint Center for Structural Genomics.]]
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<div style="clear:both"></div>
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[[Category: jcsg]]
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== References ==
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[[Category: joint center for structural genomic]]
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<references/>
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[[Category: phosphoribosylformylglycinamidine synthase]]
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__TOC__
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[[Category: protein structure initiative]]
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</StructureSection>
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[[Category: psi]]
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[[Category: Large Structures]]
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[[Category: purs subunit (ec 6 3.5 3)]]
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[[Category: Thermotoga maritima MSB8]]
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[[Category: structural genomic]]
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[[Category: tm1244]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Mar 25 23:27:49 2008''
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Current revision

Crystal structure of Phosphoribosylformylglycinamidine synthase, purS subunit (EC 6.3.5.3) (TM1244) from Thermotoga maritima at 1.90 A resolution

PDB ID 1vq3

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OCA

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