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3b84
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==Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)== | ==Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)== | ||
| - | <StructureSection load='3b84' size='340' side='right' caption='[[3b84]], [[Resolution|resolution]] 1.74Å' scene=''> | + | <StructureSection load='3b84' size='340' side='right'caption='[[3b84]], [[Resolution|resolution]] 1.74Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3b84]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3b84]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B84 FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b84 OCA], [https://pdbe.org/3b84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b84 RCSB], [https://www.ebi.ac.uk/pdbsum/3b84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b84 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TZAP_HUMAN TZAP_HUMAN] Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).<ref>PMID:24382891</ref> <ref>PMID:28082411</ref> <ref>PMID:28500257</ref> <ref>PMID:7969177</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b84_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b84_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bullock A]] |
| - | [[Category: | + | [[Category: Cooper C]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Filippakopoulos | + | [[Category: Filippakopoulos P]] |
| - | [[Category: Keates | + | [[Category: Keates T]] |
| - | [[Category: Knapp | + | [[Category: Knapp S]] |
| - | [[Category: Pike | + | [[Category: Pike ACW]] |
| - | [[Category: Pilka | + | [[Category: Pilka E]] |
| - | + | [[Category: Salah E]] | |
| - | [[Category: Salah | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Von Delft F]] |
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Current revision
Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bullock A | Cooper C | Edwards AM | Filippakopoulos P | Keates T | Knapp S | Pike ACW | Pilka E | Salah E | Weigelt J | Von Delft F
