This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3b84

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:56, 20 September 2023) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3b84.gif|left|200px]]
 
-
<!--
+
==Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)==
-
The line below this paragraph, containing "STRUCTURE_3b84", creates the "Structure Box" on the page.
+
<StructureSection load='3b84' size='340' side='right'caption='[[3b84]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3b84]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3B84 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=UNK:UNKNOWN'>UNK</scene></td></tr>
-
{{STRUCTURE_3b84| PDB=3b84 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3b84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3b84 OCA], [https://pdbe.org/3b84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3b84 RCSB], [https://www.ebi.ac.uk/pdbsum/3b84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3b84 ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/TZAP_HUMAN TZAP_HUMAN] Telomere-binding protein that acts as a regulator of telomere length (PubMed:28500257, PubMed:28082411). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28500257, PubMed:28082411). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:7969177, PubMed:24382891, PubMed:28500257). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Regulates expression the J and/or S elements in MHC II promoter (PubMed:7969177). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891).<ref>PMID:24382891</ref> <ref>PMID:28082411</ref> <ref>PMID:28500257</ref> <ref>PMID:7969177</ref>
-
 
+
== Evolutionary Conservation ==
-
==About this Structure==
+
[[Image:Consurf_key_small.gif|200px|right]]
-
3B84 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3B84 OCA].
+
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b8/3b84_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3b84 ConSurf].
 +
<div style="clear:both"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Bullock, A.]]
+
[[Category: Bullock A]]
-
[[Category: Cooper, C.]]
+
[[Category: Cooper C]]
-
[[Category: Delft, F von.]]
+
[[Category: Edwards AM]]
-
[[Category: Edwards, A M.]]
+
[[Category: Filippakopoulos P]]
-
[[Category: Filippakopoulos, P.]]
+
[[Category: Keates T]]
-
[[Category: Keates, T.]]
+
[[Category: Knapp S]]
-
[[Category: Knapp, S.]]
+
[[Category: Pike ACW]]
-
[[Category: Pike, A C.W.]]
+
[[Category: Pilka E]]
-
[[Category: Pilka, E.]]
+
[[Category: Salah E]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Weigelt J]]
-
[[Category: Salah, E.]]
+
[[Category: Von Delft F]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Activator]]
+
-
[[Category: Btb]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Hkr3]]
+
-
[[Category: Krueppel related zinc finger protein 3]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Oncogene]]
+
-
[[Category: Sgc]]
+
-
[[Category: Structural genomics consortium]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Zbtb48]]
+
-
[[Category: Zinc finger]]
+
-
[[Category: Zinc-finger]]
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 20:30:02 2008''
+

Current revision

Crystal structure of the human BTB domain of the Krueppel related Zinc Finger Protein 3 (HKR3)

PDB ID 3b84

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3b84"
Personal tools