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3bn6

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==Crystal Structure of the C2 Domain of Bovine Lactadherin at 1.67 Angstrom Resolution==
==Crystal Structure of the C2 Domain of Bovine Lactadherin at 1.67 Angstrom Resolution==
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<StructureSection load='3bn6' size='340' side='right' caption='[[3bn6]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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<StructureSection load='3bn6' size='340' side='right'caption='[[3bn6]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3bn6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3BN6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3bn6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3BN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3BN6 FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MFGE8 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9913 Bos taurus])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bn6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3bn6 RCSB], [http://www.ebi.ac.uk/pdbsum/3bn6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3bn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bn6 OCA], [https://pdbe.org/3bn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3bn6 RCSB], [https://www.ebi.ac.uk/pdbsum/3bn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3bn6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/MFGM_BOVIN MFGM_BOVIN]] Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.<ref>PMID:10821695</ref>
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[https://www.uniprot.org/uniprot/MFGM_BOVIN MFGM_BOVIN] Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction.<ref>PMID:10821695</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/3bn6_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bn/3bn6_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3bn6 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3bn6" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
</StructureSection>
[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Gilbert, G E]]
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[[Category: Large Structures]]
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[[Category: Head, J F]]
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[[Category: Gilbert GE]]
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[[Category: Novakovic, V A]]
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[[Category: Head JF]]
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[[Category: Seaton, B A]]
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[[Category: Novakovic VA]]
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[[Category: Shao, C]]
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[[Category: Seaton BA]]
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[[Category: Anti-coagulant]]
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[[Category: Shao C]]
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[[Category: Anti-coagulation]]
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[[Category: Anticoagulant]]
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[[Category: Anticoagulation]]
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[[Category: Apoptosis]]
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[[Category: Blood clotting]]
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[[Category: Blood coagulation factor v c2 homologue]]
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[[Category: Blood coagulation factor viii c2 homologue]]
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[[Category: Cell adhesion]]
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[[Category: Discoidin domain]]
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[[Category: Egf-like domain]]
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[[Category: F5_f8_type_c]]
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[[Category: Fa58c]]
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[[Category: Fertilization]]
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[[Category: Glycoprotein]]
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[[Category: Membrane binding]]
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[[Category: Milk fat globule]]
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[[Category: Phosphatidyl-serine binding]]
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[[Category: Phosphatidylserine binding]]
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Current revision

Crystal Structure of the C2 Domain of Bovine Lactadherin at 1.67 Angstrom Resolution

PDB ID 3bn6

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