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4h37

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[[Image:4h37.png|left|200px]]
 
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{{STRUCTURE_4h37| PDB=4h37 | SCENE= }}
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==Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid membranes==
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<StructureSection load='4h37' size='340' side='right'caption='[[4h37]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4h37]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Listeria_monocytogenes_EGD-e Listeria monocytogenes EGD-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H37 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h37 OCA], [https://pdbe.org/4h37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h37 RCSB], [https://www.ebi.ac.uk/pdbsum/4h37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h37 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8Y5K1_LISMO Q8Y5K1_LISMO]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Voltage-gated K(+) channels underlie the electrical excitability of cells. Each subunit of the functional tetramer consists of the tandem fusion of two modules, an N-terminal voltage-sensor and a C-terminal pore. To investigate how sensor coupling to the pore generates voltage-dependent channel opening, we solved the crystal structure and characterized the function of a voltage-gated K(+) channel pore in a lipid membrane. The structure of a functional channel in a membrane environment at 3.1 A resolution establishes an unprecedented connection between channel structure and function. The structure is unique in delineating an ion-occupied ready to conduct selectivity filter, a confined aqueous cavity, and a closed activation gate, embodying a dynamic entity trapped in an unstable closed state.
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===Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid membranes===
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Crystal Structure of a Voltage-gated K+ Channel Pore Module in a Closed State in Lipid Membranes.,Santos JS, Asmar-Rovira GA, Han GW, Liu W, Syeda R, Cherezov V, Baker KA, Stevens RC, Montal M J Biol Chem. 2012 Dec 14;287(51):43063-70. doi: 10.1074/jbc.M112.415091. Epub, 2012 Oct 24. PMID:23095758<ref>PMID:23095758</ref>
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{{ABSTRACT_PUBMED_23095758}}
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==About this Structure==
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<div class="pdbe-citations 4h37" style="background-color:#fffaf0;"></div>
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[[4h37]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Listeria_monocytogenes_egd-e Listeria monocytogenes egd-e]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H37 OCA].
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== References ==
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[[Category: Listeria monocytogenes egd-e]]
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<references/>
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[[Category: Asmar-Rovira, G A.]]
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__TOC__
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[[Category: Baker, K A.]]
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</StructureSection>
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[[Category: Cherezov, V.]]
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[[Category: Large Structures]]
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[[Category: Han, G W.]]
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[[Category: Listeria monocytogenes EGD-e]]
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[[Category: Liu, W.]]
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[[Category: Asmar-Rovira GA]]
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[[Category: Montal, M.]]
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[[Category: Baker KA]]
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[[Category: Santos, J S.]]
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[[Category: Cherezov V]]
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[[Category: Stevens, R C.]]
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[[Category: Han GW]]
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[[Category: Syeda, R.]]
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[[Category: Liu W]]
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[[Category: Ion channel]]
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[[Category: Montal M]]
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[[Category: Membrane]]
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[[Category: Santos JS]]
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[[Category: Membrane protein]]
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[[Category: Stevens RC]]
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[[Category: Module]]
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[[Category: Syeda R]]
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[[Category: Pore module]]
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Current revision

Crystal structure of a voltage-gated K+ channel pore domain in a closed state in lipid membranes

PDB ID 4h37

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