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4h43

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'''Unreleased structure'''
 
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The entry 4h43 is ON HOLD
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==Structure of the Salmonella plasmid virulence C protein (SpvC) H106N mutant.==
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<StructureSection load='4h43' size='340' side='right'caption='[[4h43]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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Authors: Shenoy, A.G., Johnson, S.J., Hengge, A.C.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4h43]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H43 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H43 FirstGlance]. <br>
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Description: Structure of the Salmonella plasmid virulence C protein (SpvC) H106N mutant.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.304&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h43 OCA], [https://pdbe.org/4h43 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h43 RCSB], [https://www.ebi.ac.uk/pdbsum/4h43 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h43 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
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[[Category: Hengge AC]]
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[[Category: Johnson SJ]]
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[[Category: Shenoy AG]]

Current revision

Structure of the Salmonella plasmid virulence C protein (SpvC) H106N mutant.

PDB ID 4h43

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