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4hl1
From Proteopedia
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| - | [[Image:4hl1.jpg|left|200px]] | ||
| - | + | ==Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin== | |
| + | <StructureSection load='4hl1' size='340' side='right'caption='[[4hl1]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4hl1]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Klebsiella_pneumoniae Klebsiella pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HL1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HL1 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZZ7:(2R,4S)-2-[(R)-{[(2R)-2-AMINO-2-PHENYLACETYL]AMINO}(CARBOXY)METHYL]-5,5-DIMETHYL-1,3-THIAZOLIDINE-4-CARBOXYLIC+ACID'>ZZ7</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hl1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hl1 OCA], [https://pdbe.org/4hl1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hl1 RCSB], [https://www.ebi.ac.uk/pdbsum/4hl1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hl1 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BLAN1_KLEPN BLAN1_KLEPN] Confers resistance to many beta-lactam antibiotics, including some carbapenems. Does not confer resistance to the polymixin colistin or the fluoroquinolone ciprofloxacin. | ||
| - | == | + | ==See Also== |
| - | + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | [[ | + | |
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[[Category: Klebsiella pneumoniae]] | [[Category: Klebsiella pneumoniae]] | ||
| - | [[Category: Babnigg | + | [[Category: Large Structures]] |
| - | [[Category: Jedrzejczak | + | [[Category: Babnigg J]] |
| - | [[Category: Joachimiak | + | [[Category: Jedrzejczak R]] |
| - | [[Category: Kim | + | [[Category: Joachimiak A]] |
| - | + | [[Category: Kim Y]] | |
| - | + | [[Category: Mire J]] | |
| - | [[Category: Mire | + | [[Category: Sacchettini J]] |
| - | [[Category: Sacchettini | + | [[Category: Tesar C]] |
| - | [[Category: Tesar | + | |
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Current revision
Crystal Structure of New Delhi Metallo-beta-Lactamase-1, Complexed with Cd and Ampicillin
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