This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
4i06
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of human Arginase-2 complexed with inhibitor 14== | ==Crystal structure of human Arginase-2 complexed with inhibitor 14== | ||
| - | <StructureSection load='4i06' size='340' side='right' caption='[[4i06]], [[Resolution|resolution]] 1.80Å' scene=''> | + | <StructureSection load='4i06' size='340' side='right'caption='[[4i06]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4i06]] is a 3 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[4i06]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I06 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X8A:[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X8A</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=X8A:[(5R)-5-CARBOXY-5-(METHYLAMINO)-7-(PIPERIDIN-1-YL)HEPTYL](TRIHYDROXY)BORATE(1-)'>X8A</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i06 OCA], [https://pdbe.org/4i06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i06 RCSB], [https://www.ebi.ac.uk/pdbsum/4i06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i06 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ARGI2_HUMAN ARGI2_HUMAN] May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 17: | Line 18: | ||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4i06" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Arginase 3D structures|Arginase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Arginase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Andreoli | + | [[Category: Large Structures]] |
| - | [[Category: Beckett | + | [[Category: Andreoli M]] |
| - | [[Category: Conway | + | [[Category: Beckett P]] |
| - | [[Category: Cousido-Siah | + | [[Category: Conway B]] |
| - | [[Category: Golebiowski | + | [[Category: Cousido-Siah A]] |
| - | [[Category: Ji | + | [[Category: Golebiowski A]] |
| - | [[Category: Mahboubi | + | [[Category: Ji M]] |
| - | [[Category: Mitschler | + | [[Category: Mahboubi K]] |
| - | [[Category: Podjarny | + | [[Category: Mitschler A]] |
| - | [[Category: Ruiz | + | [[Category: Podjarny A]] |
| - | [[Category: Schroeter | + | [[Category: Ruiz FX]] |
| - | [[Category: Sheeler | + | [[Category: Schroeter H]] |
| - | [[Category: | + | [[Category: Sheeler R]] |
| - | [[Category: | + | [[Category: Van Zandt MC]] |
| - | [[Category: Zhang | + | [[Category: Whitehouse DL]] |
| - | + | [[Category: Zhang M]] | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of human Arginase-2 complexed with inhibitor 14
| |||||||||||
Categories: Homo sapiens | Large Structures | Andreoli M | Beckett P | Conway B | Cousido-Siah A | Golebiowski A | Ji M | Mahboubi K | Mitschler A | Podjarny A | Ruiz FX | Schroeter H | Sheeler R | Van Zandt MC | Whitehouse DL | Zhang M
